SD-91 is A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. SD-91 binds to STAT3 protein with a high affinity and displays >300-fold selectivity over other STAT family protein members. SD-91 potently and effectively induces degradation of STAT3 protein and displays a high selectivity over other STAT members and >7000 non-STAT proteins in cells. A single administration of SD-91 selectively depletes STAT3 protein in tumor tissues with a persistent effect. SD-91 achieves complete and long-lasting tumor regression in the MOLM-16 xenograft model in mice even with weekly administration.
MedKoo Cat#: 464721
Name: SD-91
CAS#: 2497583-03-4 (free base)
Chemical Formula: C59H62N9O13P
Exact Mass: 1135.4205
Molecular Weight: 1136.17
Elemental Analysis: C, 62.37; H, 5.50; N, 11.10; O, 18.31; P, 2.73
The following data is based on the product molecular weight 1,136.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
