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MedKoo Cat#: 414119 | Name: Etymemazine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Etymemazine HCl is an antipsychotic, antihistamine and anticholinergic drug of the phenothiazine chemical class, structurally related to cyamemazine and methotrimeprazine.

Chemical Structure

Etymemazine HCl
Etymemazine HCl
CAS#3737-33-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 414119

Name: Etymemazine HCl

CAS#: 3737-33-5 (HCl)

Chemical Formula: C20H27ClN2S

Exact Mass: 362.1583

Molecular Weight: 362.96

Elemental Analysis: C, 66.18; H, 7.50; Cl, 9.77; N, 7.72; S, 8.83

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Related CAS #
523-54-6 (free base) 3737-33-5 (HCl)
Synonym
Etymemazine HCl; Etymemazine hydrochloride; Sergetyl; Nuital; Ethymemazine monohydrochloride; RP6484; RP-6484; RP 6484; NSC169471; NSC 169471; NSC-169471
IUPAC/Chemical Name
10-(3-(Dimethylamino)-2-methylpropyl)-2-ethylphenothiazine hydrochloride
InChi Key
ZVSKDFRXWJPINY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H26N2S.ClH/c1-5-16-10-11-20-18(12-16)22(14-15(2)13-21(3)4)17-8-6-7-9-19(17)23-20;/h6-12,15H,5,13-14H2,1-4H3;1H
SMILES Code
CCC(C=C1N2CC(C)CN(C)C)=CC=C1SC3=C2C=CC=C3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 362.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Naing PT, Acharya U, Kumar A. Hairy Cell Leukemia. 2023 May 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29763020. 2: Paillassa J, Maitre E, Troussard X. Hairy Cell Leukemia (HCL) and HCL Variant: Updates and Spotlights on Therapeutic Advances. Curr Oncol Rep. 2022 Sep;24(9):1133-1143. doi: 10.1007/s11912-022-01285-1. Epub 2022 Apr 11. PMID: 35403971. 3: Paillassa J, Safa F, Troussard X. Updates in hairy cell leukemia (HCL) and variant-type HCL (HCL-V): rationale for targeted treatments with a focus on ibrutinib. Ther Adv Hematol. 2022 Apr 13;13:20406207221090886. doi: 10.1177/20406207221090886. PMID: 35450208; PMCID: PMC9016521. 4: Shah VN, Garg SK. Standardized Hybrid Closed-Loop System Reporting. Diabetes Technol Ther. 2021 May;23(5):323-331. doi: 10.1089/dia.2020.0622. Epub 2020 Nov 25. PMID: 33252264. 5: Huang K, Zhou H, He A, Sun Y, Liu Y, Gao X, Zhao Y, Liu S, Li Z, Hu T, Li X, Liu C, Wei Y, Yang L, Feng J, Cai Y, Yang Z, Xu Y, Noda I, Wu J. Superconcentrated hydrochloric acid. J Phys Chem B. 2011 Jun 23;115(24):7823-9. doi: 10.1021/jp109551z. Epub 2011 May 26. PMID: 21615094. 6: Zhang Z, Zhang H, Wang B, Yue Y, Zhao J. Migration: A Neglected Potential Contribution of HCl-Oxidized Au(0). Molecules. 2023 Feb 7;28(4):1600. doi: 10.3390/molecules28041600. PMID: 36838588; PMCID: PMC9964448. 7: Joshi A, Dhanushkodi M, Ganesan P, Radhakrishnan V, Kannan K, Mehra N, Kalaiyarasi JP, Krupashankar S, Sundersingh S, Ganesan TS, Sagar TG. "Hairy Cell Leukemia (HCL): 'Real World' Outcome". Indian J Hematol Blood Transfus. 2020 Apr;36(2):267-270. doi: 10.1007/s12288-019-01199-2. Epub 2019 Sep 28. PMID: 32425376; PMCID: PMC7229049. 8: Liu Q, Harris N, Epperla N, Andritsos LA. Current and Emerging Therapeutic Options for Hairy Cell Leukemia Variant. Onco Targets Ther. 2021 Mar 9;14:1797-1805. doi: 10.2147/OTT.S242247. PMID: 33727830; PMCID: PMC7955867. 9: Geweke J, Wodtke AM. Vibrationally inelastic scattering of HCl from Ag(111). J Chem Phys. 2020 Oct 28;153(16):164703. doi: 10.1063/5.0026228. PMID: 33138428. 10: Swords R, Giles F. Hairy cell leukemia. Med Oncol. 2007;24(1):7-15. doi: 10.1007/BF02685898. PMID: 17673807. 11: Tiacci E, Pettirossi V, Schiavoni G, Falini B. Genomics of Hairy Cell Leukemia. J Clin Oncol. 2017 Mar 20;35(9):1002-1010. doi: 10.1200/JCO.2016.71.1556. Epub 2017 Feb 13. PMID: 28297625; PMCID: PMC5455681. 12: Sadhukhan D, Hsu PJ, Kuo JL, Patwari GN. Is Dissociation of HCl in DMSO Clusters Bistable? J Phys Chem A. 2021 Dec 9;125(48):10351-10358. doi: 10.1021/acs.jpca.1c08627. Epub 2021 Nov 25. PMID: 34821498. 13: Willers AE, Branco TB, Sahadi BO, Faraoni JJ, Dibb RGP, Giannini M. Effect of erosive challenge with HCl on restorative materials. Clin Oral Investig. 2022 Aug;26(8):5189-5203. doi: 10.1007/s00784-022-04487-w. Epub 2022 Apr 20. PMID: 35441897. 14: Paillassa J, Troussard X. Biology and Treatment of Hairy Cell Leukemia. Curr Treat Options Oncol. 2020 Apr 30;21(6):44. doi: 10.1007/s11864-020-00732-0. PMID: 32350628. 15: Jin YJ, Park J. QCM-Based HCl Gas Sensors Using Spin-Coated Aminated Polystyrene Colloids. Polymers (Basel). 2020 Jul 17;12(7):1591. doi: 10.3390/polym12071591. PMID: 32709040; PMCID: PMC7408365. 16: Borovinskaya M, Robert B, Plakogiannis FM. Evaluation of in vitro percutaneous absorption of olanzapine and fluoxetine HCl: enhancement properties of olanzapine. Drug Dev Ind Pharm. 2012 Feb;38(2):227-34. doi: 10.3109/03639045.2011.597765. Epub 2011 Aug 24. PMID: 21864096. 17: Kennedy HL, Wood AJ, MacFarland RT. Drug interactions with Ethmozine (moricizine HCl). Am J Cardiol. 1987 Oct 16;60(11):79F-82F. doi: 10.1016/0002-9149(87)90726-0. PMID: 3310590. 18: Robak T. Hairy-cell leukemia variant: recent view on diagnosis, biology and treatment. Cancer Treat Rev. 2011 Feb;37(1):3-10. doi: 10.1016/j.ctrv.2010.05.003. Epub 2010 Jun 16. PMID: 20558005. 19: Bal M, Reddy TT, Meikap BC. Removal of HCl gas from off gases using self- priming venturi scrubber. J Hazard Mater. 2019 Feb 15;364:406-418. doi: 10.1016/j.jhazmat.2018.10.028. Epub 2018 Oct 25. PMID: 30384251. 20: Gargiulo E, Giordano M, Niemann CU, Moussay E, Paggetti J, Morande PE. The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives. Front Oncol. 2023 Mar 8;13:1122699. doi: 10.3389/fonc.2023.1122699. PMID: 36968995; PMCID: PMC10031020.