MedKoo Cat#: 576782 | Name: Isamoltan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isamoltan is a 5-HT(1B) receptor antagonist. Isamoltane has reported activity as an anxiolytic in man.

Chemical Structure

Isamoltan
Isamoltan
CAS#116861-00-8 (free base)

Theoretical Analysis

MedKoo Cat#: 576782

Name: Isamoltan

CAS#: 116861-00-8 (free base)

Chemical Formula: C16H22N2O2

Exact Mass: 274.1681

Molecular Weight: 274.36

Elemental Analysis: C, 70.04; H, 8.08; N, 10.21; O, 11.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Isamoltan
IUPAC/Chemical Name
(- )-1-(Isopropylamino)-3-(o-pyrrol-1-ylphenoxy)-2-propanol.
InChi Key
XVTVPGKWYHWYAD-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H22N2O2/c1-13(2)17-11-14(19)12-20-16-8-4-3-7-15(16)18-9-5-6-10-18/h3-10,13-14,17,19H,11-12H2,1-2H3
SMILES Code
CC(C)NCC(O)COc1ccccc1n2cccc2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 274.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Lian L, Xu Y, Zhang J, Yu Y, Zhu N, Guan X, Huang H, Chen R, Chen J, Shi G, Pan J. Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT1A receptor. Neuropharmacology. 2018 Jun;135:506-513. doi: 10.1016/j.neuropharm.2018.04.003. Epub 2018 Apr 5. PMID: 29626566. 2. Diniz DA, Petrocchi JA, Navarro LC, Souza TC, Castor MG, Perez AC, Duarte ID, Romero TR. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. Eur J Pharmacol. 2015 Nov 15;767:94-7. doi: 10.1016/j.ejphar.2015.10.012. Epub 2015 Oct 13. PMID: 26460149. 3. Shimazoe T, Nakamura S, Kobayashi K, Watanabe S, Miyasaka K, Kono A, Funakoshi A. Role of 5-HT1B receptors in entrainment disorder of Otsuka Long Evans Tokushima fatty (OLETF) rats. Neuroscience. 2004;123(1):201-5. doi: 10.1016/j.neuroscience.2003.08.024. PMID: 14667454. 4. Slánský J, Kadlec O, Masek K, Gulda O. The effect of immunomodulator muramyl dipeptide on serotoninergic responses of isolated neuromuscular preparations. Pharmacology. 1994 Jan;48(1):11-20. doi: 10.1159/000139157. PMID: 8309983. 5. Slánský J, Kadlec O, Sevcík J, Masek K. Further evidence on the interaction of muramyl dipeptide with the serotonergic system. Int J Immunopharmacol. 1996 Jan;18(1):23-9. doi: 10.1016/0192-0561(95)00100-x. PMID: 8732429.