MedKoo Cat#: 414048 | Name: Eprodisate Free Base
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Eprodisate Free Base slows the decline of renal function in AA amyloidosis.

Chemical Structure

Eprodisate Free Base
Eprodisate Free Base
CAS#21668-77-9 (free base)

Theoretical Analysis

MedKoo Cat#: 414048

Name: Eprodisate Free Base

CAS#: 21668-77-9 (free base)

Chemical Formula: C3H8O6S2

Exact Mass: 203.9762

Molecular Weight: 204.21

Elemental Analysis: C, 17.64; H, 3.95; O, 47.01; S, 31.40

Price and Availability

Size Price Availability Quantity
10g USD 450.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Synonym
Eprodisate Free Base; 1,3-Propanedisulfonic acid; Propane-1,3-disulfonate; Eprodisato
IUPAC/Chemical Name
propane-1,3-disulfonic acid
InChi Key
MGNVWUDMMXZUDI-UHFFFAOYSA-N
InChi Code
InChI=1S/C3H8O6S2/c4-10(5,6)2-1-3-11(7,8)9/h1-3H2,(H,4,5,6)(H,7,8,9)
SMILES Code
OS(=O)(CCCS(=O)(O)=O)=O
Appearance
Liquid
Purity
50-60% in Water
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 204.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Manenti L, Tansinda P, Vaglio A. Eprodisate in amyloid A amyloidosis: a novel therapeutic approach? Expert Opin Pharmacother. 2008 Aug;9(12):2175-80. doi: 10.1517/14656566.9.12.2175. PMID: 18671471. 2: Manenti L, Tansinda P, Vaglio A. Eprodisate in AA amyloidosis. N Engl J Med. 2007 Sep 13;357(11):1153; author reply 1153-4. doi: 10.1056/NEJMc071922. PMID: 17855678. 3: Dember LM, Hawkins PN, Hazenberg BP, Gorevic PD, Merlini G, Butrimiene I, Livneh A, Lesnyak O, Puéchal X, Lachmann HJ, Obici L, Balshaw R, Garceau D, Hauck W, Skinner M; Eprodisate for AA Amyloidosis Trial Group. Eprodisate for the treatment of renal disease in AA amyloidosis. N Engl J Med. 2007 Jun 7;356(23):2349-60. doi: 10.1056/NEJMoa065644. PMID: 17554116. 4: Dasgupta NR, Cummings OW, Phillips CL, Benson MD. AA cardiomyopathy. Amyloid. 2017 Mar;24(sup1):138-139. doi: 10.1080/13506129.2017.1284056. PMID: 28434308. 5: Rumjon A, Coats T, Javaid MM. Review of eprodisate for the treatment of renal disease in AA amyloidosis. Int J Nephrol Renovasc Dis. 2012;5:37-43. doi: 10.2147/IJNRD.S19165. Epub 2012 Feb 24. PMID: 22427728; PMCID: PMC3304340. 6: Rule AD, Leung N. Eprodisate slows the progression of renal disease in patients with AA amyloidosis. Nat Clin Pract Nephrol. 2007 Nov;3(11):592-3. doi: 10.1038/ncpneph0615. Epub 2007 Sep 18. PMID: 17876351. 7: Zdrojewski Z. Amyloidoza w chorobach reumatycznych [Amyloidosis in rheumatic diseases]. Ann Acad Med Stetin. 2010;56 Suppl 1:7-15. Polish. PMID: 21365934. 8: Blank N, Lorenz HM. Diagnostik und Therapie der AA-Amyloidose [Diagnostics and therapy of AA amyloidosis]. Pathologe. 2009 May;30(3):219-25. German. doi: 10.1007/s00292-009-1140-5. PMID: 19333604. 9: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Apr;29(3):231-45. PMID: 17520107. 10: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2008 Apr;30(3):231-51. PMID: 18597009.