IUPAC/Chemical Name
2,6-Piperidinedione, 4-(3-(3,5-dimethyl-6-oxo-2-piperidinylidene)-2-oxopropyl)-, (3S-(2Z,3alpha,5beta))-
InChi Key
WFHHLLAMGXGSRT-ZYPOWASYSA-N
InChi Code
InChI=1S/C15H20N2O4/c1-8-3-9(2)15(21)16-12(8)7-11(18)4-10-5-13(19)17-14(20)6-10/h7-10H,3-6H2,1-2H3,(H,16,21)(H,17,19,20)/b12-7-/t8-,9-/m0/s1
SMILES Code
O=C(CC(CC(/C=C([C@@H](C)C[C@@H]1C)\NC1=O)=O)C2)NC2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
292.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Sonoda T, Osada H, Uramoto M, Uzawa J, Isono K. Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. II. Structure elucidation. J Antibiot (Tokyo). 1989 Nov;42(11):1607-9. doi: 10.7164/antibiotics.42.1607. PMID: 2486307.
6: Rani B, Cui CB, Ubukata M, Osada H. Thiazoline analogues of epiderstatin, new inhibitors of cell cycle of tsFT-210 cells. J Antibiot (Tokyo). 1995 Oct;48(10):1179-81. doi: 10.7164/antibiotics.48.1179. PMID: 7490231.
7: Sonoda T, Osada H, Uzawa J, Isono K. Actiketal, a new member of the glutarimide antibiotics. J Antibiot (Tokyo). 1991 Feb;44(2):160-3. doi: 10.7164/antibiotics.44.160. PMID: 2010356.
8: Osada H, Kikuchi K, Makishima F, Isono K. Inhibitory action of epiderstatin on EGF-stimulated growth of mouse epidermal. BALB/MK cells without direct effect on protein kinase activities. Oncol Res. 1994;6(1):11-7. PMID: 7919547.
