Synonym
ENPP1 inhibitor 43; Enpp-1-IN-12; ENPP1 inhibitor compound 43
IUPAC/Chemical Name
2-((2-amino-7H-purin-6-yl)thio)-N-(4-hydroxy-3-methoxyphenyl)butanamide
InChi Key
ZDCMJGUVFRHQEH-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H18N6O3S/c1-3-11(14(24)20-8-4-5-9(23)10(6-8)25-2)26-15-12-13(19-7-18-12)21-16(17)22-15/h4-7,11,23H,3H2,1-2H3,(H,20,24)(H3,17,18,19,21,22)
SMILES Code
COC1=CC(NC(C(CC)SC2=NC(N)=NC3=C2NC=N3)=O)=CC=C1O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
374.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Gangar M, Goyal S, Raykar D, Khurana P, Martis AM, Goswami A, Ghoshal I, Patel KV, Nagare Y, Raikar S, Mukherjee A, Cyriac R, Paquin JF, Kulkarni A. Design, synthesis and biological evaluation studies of novel small molecule ENPP1 inhibitors for cancer immunotherapy. Bioorg Chem. 2022 Feb;119:105549. doi: 10.1016/j.bioorg.2021.105549. Epub 2021 Dec 11. PMID: 34929517.
2. Marucci A, Antonucci A, De Bonis C, Mangiacotti D, Scarale MG, Trischitta V, Di Paola R. GALNT2 as a novel modulator of adipogenesis and adipocyte insulin signaling. Int J Obes (Lond). 2019 Dec;43(12):2448-2457. doi: 10.1038/s41366-019-0367-3. Epub 2019 Apr 30. PMID: 31040393.
3. Villa-Bellosta R, González-Parra E, Egido J. Alkalosis and Dialytic Clearance of Phosphate Increases Phosphatase Activity: A Hidden Consequence of Hemodialysis. PLoS One. 2016 Jul 25;11(7):e0159858. doi: 10.1371/journal.pone.0159858. PMID: 27454315; PMCID: PMC4959680.
4. Weedon MN, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM. No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians. Diabetes. 2006 Nov;55(11):3175-9. doi: 10.2337/db06-0410. PMID: 17065358.
