MedKoo Cat#: 464694 | Name: OP-1074

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OP-1074 is an aromatase inhibitors or selective estrogen receptor modulator (SERM).

Chemical Structure

OP-1074
OP-1074
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464694

Name: OP-1074

CAS#: unknown

Chemical Formula: C28H29NO4

Exact Mass: 443.2097

Molecular Weight: 443.54

Elemental Analysis: C, 75.82; H, 6.59; N, 3.16; O, 14.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
OP-1074; OP1074; OP 1074;
IUPAC/Chemical Name
(S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-(((R)-3-methylpyrrolidin-1-yl)methoxy)phenyl)-2H-chromen-7-ol
InChi Key
PQCAOJSXYBIGLG-WRHNGFHOSA-N
InChi Code
InChI=1S/C28H29NO4/c1-18-13-14-29(16-18)17-32-24-10-5-21(6-11-24)28-27(20-3-7-22(30)8-4-20)19(2)25-12-9-23(31)15-26(25)33-28/h3-12,15,18,28,30-31H,13-14,16-17H2,1-2H3/t18-,28+/m1/s1
SMILES Code
CC1=C(C2=CC=C(O)C=C2)[C@H](C3=CC=C(OCN4CC[C@@H](C)C4)C=C3)OC5=CC(O)=CC=C51
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 443.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fanning SW, Hodges-Gallagher L, Myles DC, Sun R, Fowler CE, Plant IN, Green BD, Harmon CL, Greene GL, Kushner PJ. Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity. Nat Commun. 2018 Jun 18;9(1):2368. doi: 10.1038/s41467-018-04413-3. PMID: 29915250; PMCID: PMC6006285.