MedKoo Cat#: 464643 | Name: PSMA-SulfoCy7

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSMA-SulfoCy7 is a novel PSMA ligand conjugated with fluorescent dye SulfoCy7, demonstrating good visualization of PSMA-expressing tumors and the absence of any explicit toxicity up to 87.9 mg/kg.

Chemical Structure

PSMA-SulfoCy7
PSMA-SulfoCy7
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464643

Name: PSMA-SulfoCy7

CAS#: unknown

Chemical Formula: C90H112ClN13O20S2

Exact Mass: 1793.7277

Molecular Weight: 1795.53

Elemental Analysis: C, 60.20; H, 6.29; Cl, 1.97; N, 10.14; O, 17.82; S, 3.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PSMA-SulfoCy7; PSMA SulfoCy7;
IUPAC/Chemical Name
1-(6-(((1-((3S,7S,25S,28S)-25-benzyl-1,3,7-tricarboxy-12-(3-chlorobenzyl)-28-(4-hydroxybenzyl)-5,13,20,23,26,29-hexaoxo-4,6,12,19,24,27,30-heptaazatritriacontan-33-yl)-1H-1,2,3-triazol-4-yl)methyl)amino)-6-oxohexyl)-3,3-dimethyl-2-((E)-2-((E)-3-(2-((E)-1,3,3-trimethyl-5-sulfoindolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-3H-indol-1-ium-5-sulfonate
InChi Key
RUKQDBVJHBLZJI-RNANNXKZSA-N
InChi Code
InChI=1S/C90H112ClN13O20S2/c1-89(2)69-54-67(125(119,120)121)35-38-75(69)101(5)77(89)40-31-60-22-17-23-61(50-60)32-41-78-90(3,4)70-55-68(126(122,123)124)36-39-76(70)104(78)49-15-8-11-27-79(106)94-56-65-58-103(100-99-65)48-19-46-93-84(112)73(53-62-29-33-66(105)34-30-62)96-85(113)74(52-59-20-9-6-10-21-59)95-81(108)43-42-80(107)92-45-14-7-12-28-82(109)102(57-63-24-18-25-64(91)51-63)47-16-13-26-71(86(114)115)97-88(118)98-72(87(116)117)37-44-83(110)111/h6,9-10,18,20-21,24-25,29-36,38-41,50-51,54-55,58,71-74H,7-8,11-17,19,22-23,26-28,37,42-49,52-53,56-57H2,1-5H3,(H12-,92,93,94,95,96,97,98,105,106,107,108,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124)/t71-,72-,73-,74-/m0/s1
SMILES Code
O=S(C1=CC2=C([N+](CCCCCC(NCC3=CN(CCCNC([C@H](CC4=CC=C(O)C=C4)NC([C@H](CC5=CC=CC=C5)NC(CCC(NCCCCCC(N(CC6=CC=CC(Cl)=C6)CCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)N=N3)=O)=C(/C=C/C7=C/C(CCC7)=C/C=C8N(C)C9=C(C=C(S(=O)(O)=O)C=C9)C/8(C)C)C2(C)C)C=C1)([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,795.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Machulkin AE, Shafikov RR, Uspenskaya AA, Petrov SA, Ber AP, Skvortsov DA, Nimenko EA, Zyk NU, Smirnova GB, Pokrovsky VS, Abakumov MA, Saltykova IV, Akhmirov RT, Garanina AS, Polshakov VI, Saveliev OY, Ivanenkov YA, Aladinskaya AV, Finko AV, Yamansarov EU, Krasnovskaya OO, Erofeev AS, Gorelkin PV, Dontsova OA, Beloglazkina EK, Zyk NV, Khazanova ES, Majouga AG. Synthesis and Biological Evaluation of PSMA Ligands with Aromatic Residues and Fluorescent Conjugates Based on Them. J Med Chem. 2021 Apr 22;64(8):4532-4552. doi: 10.1021/acs.jmedchem.0c01935. Epub 2021 Apr 6. PMID: 33822606.