KL-1156 | CAS#819868-62-7 | NF-κB inhibitor

MedKoo Cat#: 562699 | Name: KL-1156

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KL-1156 is a NF-κB inhibitor and lipopolysaccharide (LPS)-induced nitric oxide production inhibitor.

Chemical Structure

KL-1156

CAS#819868-62-7

Theoretical Analysis

MedKoo Cat#: 562699

Name: KL-1156

CAS#: 819868-62-7

Chemical Formula: C17H17NO4

Exact Mass: 299.1158

Molecular Weight: 299.32

Elemental Analysis: C, 68.22; H, 5.72; N, 4.68; O, 21.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KL-1156; KL 1156; KL1156;

IUPAC/Chemical Name

6-Hydroxy-7-methoxy-N-phenyl-3,4-dihydro-2H-chromene-2-carboxamide

InChi Key

JXCMRGWJFGLXJJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H17NO4/c1-21-16-10-15-11(9-13(16)19)7-8-14(22-15)17(20)18-12-5-3-2-4-6-12/h2-6,9-10,14,19H,7-8H2,1H3,(H,18,20)

SMILES Code

O=C(C1CCC2=C(O1)C=C(OC)C(O)=C2)NC3=CC=CC=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 299.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Choi M, Jo H, Park HJ, Sateesh Kumar A, Lee J, Yun J, Kim Y, Han SB, Jung JK, Cho J, Lee K, Kwak JH, Lee H. Design, synthesis, and biological evaluation of benzofuran- and 2,3-dihydrobenzofuran-2-carboxylic acid N-(substituted)phenylamide derivatives as anticancer agents and inhibitors of NF-κB. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2545-9. doi: 10.1016/j.bmcl.2015.04.050. Epub 2015 Apr 23. PubMed PMID: 25953156. 2: Choi M, Hwang YS, Kumar AS, Jo H, Jeong Y, Oh Y, Lee J, Yun J, Kim Y, Han SB, Jung JK, Cho J, Lee H. Design and synthesis of 3,4-dihydro-2H-benzo[h]chromene derivatives as potential NF-κB inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2404-7. doi: 10.1016/j.bmcl.2014.04.053. Epub 2014 Apr 20. PubMed PMID: 24792464. 3: Kwak JH, Won SW, Kim TJ, Yi W, Choi EH, Kim SC, Park H, Roh E, Jung JK, Hwang BY, Hong JT, Kim Y, Cho J, Lee H. Synthesis and nuclear factor-kappaB inhibitory activities of 6- or 7-methylchroman-2-carboxylic acid N-(substituted) phenylamides. Arch Pharm Res. 2009 Feb;32(2):167-75. doi: 10.1007/s12272-009-1131-3. Epub 2009 Mar 13. PubMed PMID: 19280144. 4: Kwak JH, Won SW, Kim TJ, Roh E, Kang HY, Lee HW, Jung JK, Hwang BY, Kim Y, Cho J, Lee H. Synthesis of chroman-2-carboxylic acid N-(substituted)phenylamides and their inhibitory effect on nuclear factor-kappaB (NF-kappaB) activation. Arch Pharm Res. 2008 Feb;31(2):133-41. PubMed PMID: 18365680. 5: Kwak JH, Kim BH, Jung JK, Kim Y, Cho J, Lee H. Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kappaB activation. Arch Pharm Res. 2007 Oct;30(10):1210-5. PubMed PMID: 18038899. 6: Rak Min K, Lee H, Hak Kim B, Chung E, Min Cho S, Kim Y. Inhibitory effect of 6-hydroxy-7-methoxychroman-2-carboxylic acid phenylamide on nitric oxide and interleukin-6 production in macrophages. Life Sci. 2005 Nov 4;77(25):3242-57. Epub 2005 Jun 22. PubMed PMID: 15978634. 7: Kim BH, Reddy AM, Lee KH, Chung EY, Cho SM, Lee H, Min KR, Kim Y. Inhibitory mechanism of chroman compound on LPS-induced nitric oxide production and nuclear factor-kappaB activation. Biochem Biophys Res Commun. 2004 Dec 3;325(1):223-8. PubMed PMID: 15522222.