Synonym
Rp-cAMPS TEA salt; Rp cAMPS TEA salt; Rp-cAMPS TEA; Rp cAMPS TEA;
IUPAC/Chemical Name
(2R,6R,7S)-6-(6-amino-9H-purin-9-yl)-7-hydroxy-2-mercaptotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide, triethylammonium salt
InChi Key
OXIPZMKSNMRTIV-FCRSUSRCSA-O
InChi Code
InChI=1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/p+1/t4?,6-,7?,10+,21+;/m0./s1
SMILES Code
S[P@@]1(OCC(O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H]4O)C4O1)=O.CC[NH+](CC)CC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
447.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kang KB, van der Zypp A, Majewski H. Endogenous nitric oxide attenuates beta-adrenoceptor-mediated relaxation in rat aorta. Clin Exp Pharmacol Physiol. 2007 Jan-Feb;34(1-2):95-101. PubMed PMID: 17201742.
2: Hess G. Synaptic plasticity of local connections in rat motor cortex. Acta Neurobiol Exp (Wars). 2004;64(2):271-6. Review. PubMed PMID: 15366258.
3: Grzegorzewska M, Przybylo M, Litynska A, Hess G. Chemically-induced long-term potentiation in rat motor cortex involves activation of extracellular signal-regulated kinase cascade. Brain Res. 2004 Sep 24;1021(2):192-9. PubMed PMID: 15342267.
4: Hayashi M, Kunii C, Takahata T, Ishikawa T. ATP-dependent regulation of SK4/IK1-like currents in rat submandibular acinar cells: possible role of cAMP-dependent protein kinase. Am J Physiol Cell Physiol. 2004 Mar;286(3):C635-46. Epub 2003 Nov 5. PubMed PMID: 14602578.
5: Huang Y, Chan FL, Lau CW, Tsang SY, Chen ZY, He GW, Yao X. Roles of cyclic AMP and Ca2+-activated K+ channels in endothelium-independent relaxation by urocortin in the rat coronary artery. Cardiovasc Res. 2003 Mar;57(3):824-33. PubMed PMID: 12618244.
6: Haug T, Storm JF. Protein kinase A mediates the modulation of the slow Ca(2+)-dependent K(+) current, I(sAHP), by the neuropeptides CRF, VIP, and CGRP in hippocampal pyramidal neurons. J Neurophysiol. 2000 Apr;83(4):2071-9. PubMed PMID: 10758117.
7: Lee AK, Tse A. Mechanism underlying corticotropin-releasing hormone (CRH) triggered cytosolic Ca2+ rise in identified rat corticotrophs. J Physiol. 1997 Oct 15;504 ( Pt 2):367-78. PubMed PMID: 9365911; PubMed Central PMCID: PMC1159917.
8: Maggi CA, Giuliani S. Characterization of the apamin- and L-nitroarginine-resistant NANC inhibitory transmission to the circular muscle of guinea-pig colon. J Auton Pharmacol. 1996 Jun;16(3):131-45. PubMed PMID: 8884460.
9: Haynes J Jr, Robinson J, Saunders L, Taylor AE, Strada SJ. Role of cAMP-dependent protein kinase in cAMP-mediated vasodilation. Am J Physiol. 1992 Feb;262(2 Pt 2):H511-6. PubMed PMID: 1311530.