Synonym
Miboplatin; CCRIS5235; CCRIS-5235; CCRIS 5235; DWA2114R; DWA-2114R; DWA 2114R
IUPAC/Chemical Name
(-)-(R)-2-Aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum(II) hydrate
InChi Key
XXUHLUDUCZQMDI-UTYJZAQGSA-L
InChi Code
InChI=1S/C6H8O4.C5H12N2.Pt/c7-4(8)6(5(9)10)2-1-3-6;6-4-5-2-1-3-7-5;/h1-3H2,(H,7,8)(H,9,10);5,7H,1-4,6H2;/q;;+2/p-2/t;5-;/m.1./s1
SMILES Code
NC[C@H]1CCCN1.[O-]C(C2(C([O-])=O)CCC2)=O.[Pt+2]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
437.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Kubota N, Kakehi M, Inada T. Hyperthermic enhancement of cell killing by five platinum complexes in human malignant melanoma cells grown as monolayer cultures and multicellular spheroids. Int J Radiat Oncol Biol Phys. 1993 Feb 15;25(3):491-7. doi: 10.1016/0360-3016(93)90071-3. PMID: 8436528.
6: Majima H. [Present status of cisplatin (CDDP) analogues in Japan]. Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 2-2):1373-8. Japanese. PMID: 2658825.
7: Iwata M, Izuta S, Suzuki M, Kojima K, Furuhashi Y, Tomoda Y, Yoshida S. Sequence-dependent termination of mammalian DNA polymerase reaction by a new platinum compound, (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutane- dicarboxylato)-2-plati num(II) monohydrate). Jpn J Cancer Res. 1991 Apr;82(4):433-9. doi: 10.1111/j.1349-7006.1991.tb01867.x. PMID: 1904423; PMCID: PMC5918450.
8: Ota K. [Cisplatinum compounds]. Gan To Kagaku Ryoho. 1993 Jan;20(1):50-8. Japanese. PMID: 8380687.
9: Endoh K, Akamatsu K, Matsumoto T, Morikawa K, Honda M, Mitsui H, Koizumi M, Koizumi K, Matsuno T. Antitumor activity of a new platinum complex, 2-aminomethyl-pyrrolidine (1, 1-cyclobutanedicarboxylato) platinum (II). Anticancer Res. 1989 Jul-Aug;9(4):987-91. PMID: 2817826.
10: Ariyoshi Y, Ota K. [Preclinical and clinical evaluation of toxicity and antitumor activity of cisplatin analogues]. Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 2-2):1379-85. Japanese. PMID: 2658826.
