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MedKoo Cat#: 526269 | Name: Photoregulin1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Photoregulin1 is a novel modulator of Nr2e3, slowing the progression of photoreceptor degeneration in two common mouse models of autosomal dominant RP, the RhoP23H and the Pde6brd1 mutations.

Chemical Structure

Photoregulin1
Photoregulin1
CAS#1003736-23-9

Theoretical Analysis

MedKoo Cat#: 526269

Name: Photoregulin1

CAS#: 1003736-23-9

Chemical Formula: C21H23N3O2S

Exact Mass: 381.1511

Molecular Weight: 381.49

Elemental Analysis: C, 66.12; H, 6.08; N, 11.01; O, 8.39; S, 8.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Photoregulin1
IUPAC/Chemical Name
N-(3,5-Dimethyl-phenyl)-3-(4-oxo-3,4,5,6,7,8-hexahydro-benzo[4,5]thieno[2,3-d]pyrimidin-2-yl)-propionamide
InChi Key
HGXMLGSUGNEINU-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H23N3O2S/c1-12-9-13(2)11-14(10-12)22-18(25)8-7-17-23-20(26)19-15-5-3-4-6-16(15)27-21(19)24-17/h9-11H,3-8H2,1-2H3,(H,22,25)(H,23,24,26)
SMILES Code
O=C(NC1=CC(C)=CC(C)=C1)CCC2=NC3=C(C4=C(CCCC4)S3)C(N2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 381.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nakamura PA, Tang S, Shimchuk AA, Ding S, Reh TA. Potential of Small Molecule-Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6407-6415. doi: 10.1167/iovs.16-20177. PubMed PMID: 27893103; PubMed Central PMCID: PMC5134355.