MedKoo Cat#: 555984 | Name: TKN87180
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TKN87180 is a Hydrolyzable linker for making ADC conjugate. TKN87180 was first reported in Bioorganic & Medicinal Chemistry Letters (2004), 14(16), 4323-4327. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

TKN87180
TKN87180
CAS#756487-18-0

Theoretical Analysis

MedKoo Cat#: 555984

Name: TKN87180

CAS#: 756487-18-0

Chemical Formula: C37H49N5O8

Exact Mass: 691.3581

Molecular Weight: 691.83

Elemental Analysis: C, 64.24; H, 7.14; N, 10.12; O, 18.50

Price and Availability

Size Price Availability Quantity
100mg USD 1,150.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 5,850.00 2 Weeks
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Related CAS #
No Data
Synonym
TKN87180; TKN-87180; TKN 87180;
IUPAC/Chemical Name
tert-butyl ((S)-5-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-phenylpropanamido)-6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexyl)carbamate
InChi Key
TUPIPBYBJMCLLM-KYJUHHDHSA-N
InChi Code
InChI=1S/C37H49N5O8/c1-37(2,3)50-36(49)38-22-10-9-14-29(34(47)39-28-18-16-27(25-43)17-19-28)41-35(48)30(24-26-12-6-4-7-13-26)40-31(44)15-8-5-11-23-42-32(45)20-21-33(42)46/h4,6-7,12-13,16-21,29-30,43H,5,8-11,14-15,22-25H2,1-3H3,(H,38,49)(H,39,47)(H,40,44)(H,41,48)/t29-,30-/m0/s1
SMILES Code
O=C([C@@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CC2=CC=CC=C2)=O)CCCCNC(OC(C)(C)C)=O)NC3=CC=C(C=C3)CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 691.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Walker MA, King HD, Dalterio RA, Trail P, Firestone R, Dubowchik GM. Monoclonal antibody mediated intracellular targeting of tallysomycin S(10b). Bioorg Med Chem Lett. 2004 Aug 16;14(16):4323-7. doi: 10.1016/j.bmcl.2004.05.089. PMID: 15261295.