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MedKoo Cat#: 596338 | Name: Trimecaine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trimecaine is an acetanilide derivative used as a local anesthetic.

Chemical Structure

Trimecaine
Trimecaine
CAS#616-68-2

Theoretical Analysis

MedKoo Cat#: 596338

Name: Trimecaine

CAS#: 616-68-2

Chemical Formula: C15H24N2O

Exact Mass: 248.1889

Molecular Weight: 248.37

Elemental Analysis: C, 72.54; H, 9.74; N, 11.28; O, 6.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Trimecaine; Diethylglycinemesidide; Mesidicaine; EINECS 210-487-3; BRN 2697351; BRN-2697351; BRN2697351;
IUPAC/Chemical Name
2-(diethylamino)-N-mesitylacetamide
InChi Key
GOZBHBFUQHMKQB-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H24N2O/c1-6-17(7-2)10-14(18)16-15-12(4)8-11(3)9-13(15)5/h8-9H,6-7,10H2,1-5H3,(H,16,18)
SMILES Code
O=C(NC1=C(C)C=C(C)C=C1C)CN(CC)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 248.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hart R, Wendsche P, Kočiš J, Komzák M, Okál F, Krejzla J. [Injection of anaesthetic-corticosteroid to relieve sacroiliac joint pain after lumbar stabilisation]. Acta Chir Orthop Traumatol Cech. 2011;78(4):339-42. Czech. PubMed PMID: 21888845. 2: Matoušek P, Komínek P, Garčic A. Errors associated with the concentration of epinephrine in endonasal surgery. Eur Arch Otorhinolaryngol. 2011 Jul;268(7):1009-11. doi: 10.1007/s00405-010-1435-4. Epub 2011 Feb 17. PubMed PMID: 21328004. 3: Plevkova J, Antosiewicz J, Varechova S, Poliacek I, Jakus J, Tatar M, Pokorski M. Convergence of nasal and tracheal neural pathways in modulating the cough response in guinea pigs. J Physiol Pharmacol. 2009 Jun;60(2):89-93. PubMed PMID: 19617651. 4: Stoliarov EE, Karpenko IuN, Malkova TL. [Detection of certain local anesthetics in biological fluids by chemo-toxicological analysis]. Sud Med Ekspert. 2009 May-Jun;52(3):24-7. Russian. PubMed PMID: 19569536. 5: Tomek V, Skovranek J, Gebauer RA. Prenatal diagnosis and management of fetal Long QT syndrome. Pediatr Cardiol. 2009 Feb;30(2):194-6. doi: 10.1007/s00246-008-9294-0. Epub 2008 Aug 15. Erratum in: Pediatr Cardiol. 2009 Nov;30(8):1197. PubMed PMID: 18709401. 6: Dostalova V, Visnovsky P, Dostal P. The epidural postoperative analgesia after a major urological procedures--a comparison of trimecaine and morphine to bupivacaine and fentanyl. Bratisl Lek Listy. 2008;109(3):111-5. PubMed PMID: 18517133. 7: Lisková A, Blesová M. [Potentiometric determination of aqueous dissociation constants of 2-,3-,4-{3-(4-benzhydryl-piperazine-1-yl)-2-hydroxy-propoxy}-phenylcarbamic acid alkylesters, water insoluble potential blockers of beta-adrenergic receptors]. Ceska Slov Farm. 2006 Nov;55(6):272-7. Slovak. PubMed PMID: 17288063. 8: Vajner L, Uhlík J, Konrádová V, Klescová A, Adásková J. Local administration of 2% trimecaine affects the content of fucosylated glycoconjugates in goblet cells in rabbit tracheal epithelium. Int J Exp Pathol. 2006 Aug;87(4):283-8. PubMed PMID: 16875493; PubMed Central PMCID: PMC2517373. 9: Balashov VP, Blinov DS, Kazachenko VN, Astashev ME, Agenosova OG. Membrane mechanisms of antiarrhythmic effect of quaternidine. Bull Exp Biol Med. 2005 Jun;139(6):688-91. PubMed PMID: 16224582. 10: Subová M, Vitková Z, Cirbusová E, Erös I, Kónya M. [Effect of polymer concentration on rheological properties of Carbopol 980 hydrogels containing trimecainium chloride]. Ceska Slov Farm. 2005 Mar;54(2):96-9. Slovak. PubMed PMID: 15895974. 11: Blinov DS, Kostin IaV, Volkova ND. [Effect of trimecaine derivatives and lidocaine on hemodynamics]. Eksp Klin Farmakol. 2004 Mar-Apr;67(2):24-6. Russian. PubMed PMID: 15188755. 12: Moiseeva IIa, Blinov DS, Kostin IaV. [Study of antiarrhythmic activity and duration of action of quaternidine]. Eksp Klin Farmakol. 2003 Sep-Oct;66(5):22-4. Russian. PubMed PMID: 14650209. 13: Kostin IaV, Blinov DS, Moiseeva IIa. [The antiarrhythmic activity of the trimecain ammonium derivative in myocardial ischemia]. Eksp Klin Farmakol. 2003 May-Jun;66(3):29-31. Russian. PubMed PMID: 12924229. 14: Vach B, Kurzová A, Málek J, Fanta J, Pachl J. [Infiltration of local anesthetics into the thyroid gland capsule for surgery and the postoperative period]. Rozhl Chir. 2002 Oct;81(10):519-22. Czech. PubMed PMID: 12564092. 15: Golovanenko AL, Oleshko LN, Iushkova TA, Odegova TF, Zarivchatskiĭ MF, Mugatarov IN, Khokhlova RN, Balakshin NA. [Laboratory and clinical study of therapeutic efficacy of medicinal films for surgical procedures]. Eksp Klin Farmakol. 2002 May-Jun;65(3):71-4. Russian. PubMed PMID: 12227104. 16: Vajner L, Konrádová V, Uhlík J, Zocová J. The effect of local administration of 2% trimecaine on the glycoconjugate content of goblet cells in the rabbit tracheal epithelium. Sb Lek. 2001;102(2):233-6. PubMed PMID: 12092112. 17: Kurbatova GT, Fedorenko OM, Sokhov ST, Verkholomova IA, Shklovskaia NI. [Magnetically-guided anesthetics based on highly dispersed iron powders coated by polyacrylamide]. Biofizika. 2002 Mar-Apr;47(2):331-7. Russian. PubMed PMID: 11969173. 18: Shtutin SA. [Some aspects of epidural anesthesia in patients with chronic renal insufficiency]. Lik Sprava. 2001 Jul-Aug;(4):112-5. Russian. PubMed PMID: 11692688. 19: Isaev GA, Dmitriev AV, Isaev PP. [Mechanism of local anesthesia: long-range orientation effects]. Biofizika. 2000 Nov-Dec;45(6):1066-71. Russian. PubMed PMID: 11155234. 20: Salajka F. The role of local anaesthetic inhalation during premedication before bronchoscopy. Wien Klin Wochenschr. 1999 Dec 23;111(24):1031-4. PubMed PMID: 10677890.