MedKoo Cat#: 555982 | Name: NSC-92828
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-92828, also known as 3-Phenanthrenebutyric acid, is a Protein–protein interaction inhibitor (2P2 inhibitor or 2P2I). Protein–protein recognition is the cornerstone of multiple cellular and pathological functions. Therefore, protein–protein interaction inhibition (2P2I) is endowed with great therapeutic potential despite the initial belief that 2P2I was refractory to small-molecule intervention.

Chemical Structure

NSC-92828
NSC-92828
CAS#13728-56-8

Theoretical Analysis

MedKoo Cat#: 555982

Name: NSC-92828

CAS#: 13728-56-8

Chemical Formula: C18H16O2

Exact Mass: 264.1150

Molecular Weight: 264.32

Elemental Analysis: C, 81.79; H, 6.10; O, 12.11

Price and Availability

Size Price Availability Quantity
500mg USD 2,650.00 2 Weeks
1g USD 3,950.00 2 Weeks
2g USD 6,950.00 2 Weeks
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Related CAS #
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Synonym
NSC-92828; NSC 92828; NSC92828; 3-Phenanthrenebutyric acid; HIV-1 Nef-IN-1
IUPAC/Chemical Name
3-Phenanthrenebutyric acid
InChi Key
NYIVWTWKIQOBKO-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H16O2/c19-18(20)7-3-4-13-8-9-15-11-10-14-5-1-2-6-16(14)17(15)12-13/h1-2,5-6,8-12H,3-4,7H2,(H,19,20)
SMILES Code
O=C(O)CCCC1=CC=C2C=CC3=CC=CC=C3C2=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
HIV-1 Nef-IN-1 is an HIV-1 Nef protein inhibitor that efficiently competes for Nef-SH3Hck interactions with a Kd of 6.7 μM.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 264.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Betzi S, Restouin A, Opi S, Arold ST, Parrot I, Guerlesquin F, Morelli X, Collette Y. Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19256-61. doi: 10.1073/pnas.0707130104. Epub 2007 Nov 27. PMID: 18042718; PMCID: PMC2148277.