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MedKoo Cat#: 462158 | Name: iFSP1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

iFSP1 is a ferroptosis suppressor protein 1 (FSP1) inhibitor and ferroptosis inducer.

Chemical Structure

iFSP1
iFSP1
CAS#150651-39-1

Theoretical Analysis

MedKoo Cat#: 462158

Name: iFSP1

CAS#: 150651-39-1

Chemical Formula: C20H13N5

Exact Mass: 323.1171

Molecular Weight: 323.36

Elemental Analysis: C, 74.29; H, 4.05; N, 21.66

Price and Availability

Size Price Availability Quantity
10mg USD 80.00 Ready to ship
25mg USD 150.00 Ready to ship
50mg USD 250.00 Ready to ship
100mg USD 425.00 Ready to ship
200mg USD 750.00 Ready to ship
500mg USD 1,450.00 Ready to ship
1g USD 2,650.00 2 Weeks
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Related CAS #
No Data
Synonym
iFSP1; iFSP-1; iFSP 1;
IUPAC/Chemical Name
1-amino-3-(p-tolyl)benzo[4,5]imidazo[1,2-a]pyridine-2,4-dicarbonitrile
InChi Key
FNESYDFRCQEEKA-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H13N5/c1-12-6-8-13(9-7-12)18-14(10-21)19(23)25-17-5-3-2-4-16(17)24-20(25)15(18)11-22/h2-9H,23H2,1H3
SMILES Code
NC1=C(C#N)C(C2=CC=C(C)C=C2)=C(C#N)C3=NC4=C(C=CC=C4)N31
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 30.0 92.78
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 323.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M. Phase separation of FSP1 promotes ferroptosis. Nature. 2023 Jul;619(7969):371-377. doi: 10.1038/s41586-023-06255-6. Epub 2023 Jun 28. PMID: 37380771; PMCID: PMC10338336. 2: Xavier da Silva TN, Schulte C, Alves AN, Maric HM, Friedmann Angeli JP. Molecular characterization of AIFM2/FSP1 inhibition by iFSP1-like molecules. Cell Death Dis. 2023 Apr 21;14(4):281. doi: 10.1038/s41419-023-05787-z. PMID: 37080964; PMCID: PMC10119282. 3: Cheu JW, Lee D, Li Q, Goh CC, Bao MH, Yuen VW, Zhang MS, Yang C, Chan CY, Tse AP, Sit GF, Liu CX, Ng IO, Wong CM, Wong CC. Ferroptosis Suppressor Protein 1 Inhibition Promotes Tumor Ferroptosis and Anti-tumor Immune Responses in Liver Cancer. Cell Mol Gastroenterol Hepatol. 2023;16(1):133-159. doi: 10.1016/j.jcmgh.2023.03.001. Epub 2023 Mar 7. PMID: 36893885; PMCID: PMC10230009. 4: Nakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B, Conrad M. Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation. Nat Struct Mol Biol. 2023 Nov;30(11):1806-1815. doi: 10.1038/s41594-023-01136-y. Epub 2023 Nov 13. PMID: 37957306; PMCID: PMC10643123. 5: Miao H, Meng H, Zhang Y, Chen T, Zhang L, Cheng W. FSP1 inhibition enhances olaparib sensitivity in BRCA-proficient ovarian cancer patients via a nonferroptosis mechanism. Cell Death Differ. 2024 Apr;31(4):497-510. doi: 10.1038/s41418-024-01263-z. Epub 2024 Feb 19. PMID: 38374229; PMCID: PMC11043371. 6: Yong YY, Yan L, Wang BD, Fan DS, Guo MS, Yu L, Wu JM, Qin DL, Law BY, Wong VK, Yu CL, Zhou XG, Wu AG. Penthorum chinense Pursh inhibits ferroptosis in cellular and Caenorhabditis elegans models of Alzheimer's disease. Phytomedicine. 2024 May;127:155463. doi: 10.1016/j.phymed.2024.155463. Epub 2024 Feb 16. PMID: 38452694. 7: Tao H, Dar HY, Tian C, Banerjee S, Glazer ES, Srinivasan S, Zhu L, Pacifici R, He P. Differences in hepatocellular iron metabolism underlie sexual dimorphism in hepatocyte ferroptosis. Redox Biol. 2023 Nov;67:102892. doi: 10.1016/j.redox.2023.102892. Epub 2023 Sep 17. PMID: 37741044; PMCID: PMC10519854. 8: Zhou J, Zhang L, Yan J, Hou A, Sui W, Sun M. Curcumin Induces Ferroptosis in A549 CD133+ Cells through the GSH-GPX4 and FSP1-CoQ10-NAPH Pathways. Discov Med. 2023 Jun;35(176):251-263. doi: 10.24976/Discov.Med.202335176.26. PMID: 37272092. 9: Zhu H, Yang Y, Duan Y, Zheng X, Lin Z, Zhou J. Nrf2/FSP1/CoQ10 axis-mediated ferroptosis is involved in sodium aescinate-induced nephrotoxicity. Arch Biochem Biophys. 2024 Sep;759:110100. doi: 10.1016/j.abb.2024.110100. Epub 2024 Jul 20. PMID: 39033970. 10: Wu YC, Huang CS, Hsieh MS, Huang CM, Setiawan SA, Yeh CT, Kuo KT, Liu SC. Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis. Aging (Albany NY). 2024 Jan 10;16(1):627-647. doi: 10.18632/aging.205409. Epub 2024 Jan 10. PMID: 38206305; PMCID: PMC10817390.