Synonym
Doxantrazole; NSC311586; NSC-311586; NSC 311586
IUPAC/Chemical Name
3-(1H-Tetrazol-5-yl)-9H-thioxanthen-9-one 10,10-dioxide
InChi Key
VIDCTSLIEZMQRF-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H8N4O3S/c19-13-9-3-1-2-4-11(9)22(20,21)12-7-8(5-6-10(12)13)14-15-17-18-16-14/h1-7H,(H,15,16,17,18)
SMILES Code
O=C1C2=C(S(C3=C1C=CC=C3)(=O)=O)C=C(C4=NN=NN4)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
312.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sadeghi-Hashjin G, Nijkamp FP, Henricks PA, Folkerts G. Sodium cromoglycate and doxantrazole are oxygen radical scavengers. Eur Respir J. 2002 Oct;20(4):867-72. doi: 10.1183/09031936.02.00382002. PMID: 12412677.
2: Poppius H, Stenius B. Exercise-induced asthma and doxantrazole. Eur J Clin Pharmacol. 1977 Jan 3;11(2):107-9. doi: 10.1007/BF00562900. PMID: 837962.
3: Gribbin HR, Harvey JE, Tattersfield AE. Trial of doxantrazole in asthma. Br Med J. 1979 Jan 13;1(6156):92. doi: 10.1136/bmj.1.6156.92. PMID: 104761; PMCID: PMC1598193.
4: Bentley-Phillips CB, Eady RA, Greaves MW. Cold urticaria: inhibition of cold- induced histamine release by doxantrazole. J Invest Dermatol. 1978 Oct;71(4):266-8. doi: 10.1111/1523-1747.ep12515101. PMID: 81244.
5: Shimbori C, Upagupta C, Bellaye PS, Ayaub EA, Sato S, Yanagihara T, Zhou Q, Ognjanovic A, Ask K, Gauldie J, Forsythe P, Kolb MRJ. Mechanical stress-induced mast cell degranulation activates TGF-β1 signalling pathway in pulmonary fibrosis. Thorax. 2019 May;74(5):455-465. doi: 10.1136/thoraxjnl-2018-211516. Epub 2019 Feb 26. PMID: 30808717.
6: Foreman JC, Hallett MB, Mongar JL. Site of action of the antiallergic drugs cromoglycate and doxantrazole [proceedings]. Br J Pharmacol. 1977 Mar;59(3):473P-474P. PMID: 402969; PMCID: PMC1668031.
7: Spitzer JC. Interaction of doxantrazole with calcium ions in solvents of intermediate polarity. Possible effect of ionization of the drug. Int Arch Allergy Appl Immunol. 1980;61(1):75-80. doi: 10.1159/000232417. PMID: 6101277.
8: Batchelor JF, Follenfant MJ, Garland LG, Gorvin JH, Green AF, Hodson HF, Hughes DT, Tateson JE. Doxantrazole, an antiallergic agent orally effective in man. Lancet. 1975 May 24;1(7917):1169-70. doi: 10.1016/s0140-6736(75)93141-4. PMID: 48779.
9: Pauwels R, Lamont H, van der Straeten M. The effect of oral doxantrazole on allergen-induced bronchospasm. Acta Allergol. 1976 Jun;31(3):239-44. doi: 10.1111/j.1398-9995.1976.tb01684.x. PMID: 821299.
10: Pauwels R, Lamont H, van der Straeten M. Further studies on the effect of oral doxantrazole on allergen-induced bronchospasm. Acta Allergol. 1976 Dec;31(6):471-7. doi: 10.1111/j.1398-9995.1976.tb01497.x. PMID: 797216.
