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MedKoo Cat#: 526169 | Name: Ro 23-0364

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 23-0364 a novel imidazobenzodiazepine with mixed benzodiazepine agonist/antagonist properties.

Chemical Structure

Ro 23-0364
Ro 23-0364
CAS#113066-25-4

Theoretical Analysis

MedKoo Cat#: 526169

Name: Ro 23-0364

CAS#: 113066-25-4

Chemical Formula: C18H13ClN4O

Exact Mass: 336.0778

Molecular Weight: 336.78

Elemental Analysis: C, 64.20; H, 3.89; Cl, 10.53; N, 16.64; O, 4.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 23-0364; Ro 230364; Ro-23-0364.
IUPAC/Chemical Name
6-(2-chlorophenyl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxamide
InChi Key
BKRBQMJIWKNKJO-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H13ClN4O/c19-13-7-3-1-5-11(13)16-12-6-2-4-8-14(12)23-10-22-17(18(20)24)15(23)9-21-16/h1-8,10H,9H2,(H2,20,24)
SMILES Code
O=C(C1=C2N(C=N1)C3=CC=CC=C3C(C4=CC=CC=C4Cl)=NC2)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 336.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yakushiji T, Fukuda T, Oyama Y, Akaike N. Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones. Br J Pharmacol. 1989 Nov;98(3):735-40. PubMed PMID: 2574062; PubMed Central PMCID: PMC1854765. 2: Yerbury RE, Cooper SJ. Novel benzodiazepine receptor ligands: palatable food intake following zolpidem, CGS 17867A, or Ro23-0364, in the rat. Pharmacol Biochem Behav. 1989 Jun;33(2):303-7. PubMed PMID: 2573076. 3: Cooper SJ, Desa A. Benzodiazepines and putative 5-HT1A agonists increase hypertonic saline consumption in rehydrating rats. Pharmacol Biochem Behav. 1987 Oct;28(2):187-91. PubMed PMID: 2825218. 4: Saletu B, Grünberger J, Cepko H. Pharmaco-EEG and psychometric studies with a novel selective benzodiazepine agonist/antagonist Ro 23-0364. Int J Clin Pharmacol Ther Toxicol. 1987 Aug;25(8):421-37. PubMed PMID: 2888736. 5: Cooper SJ, Yerbury RE, Neill JC, Desa A. Partial agonists acting at benzodiazepine receptors can be differentiated in tests of ingestional behaviour. Physiol Behav. 1987;41(3):247-55. Review. PubMed PMID: 2829244.