Synonym
Nitroxinil; CCRIS5743; CCRIS-5743; CCRIS 5743
IUPAC/Chemical Name
4-Hydroxy-3-iodo-5-nitrobenzonitrile
InChi Key
SGKGVABHDAQAJO-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H3IN2O3/c8-5-1-4(3-9)2-6(7(5)11)10(12)13/h1-2,11H
SMILES Code
N#CC1=CC([N+]([O-])=O)=C(O)C(I)=C1
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Nitroxinil is an anthelmintic agent.
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| DMSO |
100.0 |
344.81 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
290.02
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Irazoqui I, Rodriguez A, Birriel E, Gabay M, Lavaggi ML, Repetto JL, Cajarville C, Gonzalez M, Cerecetto H. Anaerobic metabolism of the agro- pesticide nitroxinil by bovine ruminal fluid. Drug Metab Lett. 2014;8(2):101-8. doi: 10.2174/1872312809666141208150629. PMID: 25496284.
2: Baziard-Mouysset G, Alvinerie M, Galtier P, Ane-Margail M, Floch R, Payard M. Etude de l'hydrolyse plasmatique et hépatique de dérivés du Nitroxinil [Study of plasma and hepatic hydrolysis of nitroxinil derivatives]. Ann Pharm Fr. 1996;54(5):223-7. French. PMID: 8953797.
3: González-Garduño R, Ortiz-Pérez DO, Alegría-Jiménez L, Torres-Chable OM, Cruz-Tamayo AA, Zaragoza-Vera CV. Evaluation of anthelmintic drugs against egg development of rumen flukes recovered from cattle raised in the humid tropics of Mexico. J Helminthol. 2020 Aug 10;94:e177. doi: 10.1017/S0022149X20000607. PMID: 32772957.
4: Delavenay RP. Emploi du nitroxynil chez le dromadaire. Essais de toxicité et d'efficacité réalisés en Ethiopie [Use of nitroxinil in the camel. Trials on its toxicity and effectiveness performed in Ethiopia]. Rev Elev Med Vet Pays Trop. 1978;31(2):171-7. French. PMID: 734203.
5: Hu SX, Mazur CA, Feenstra KL. Assessment of Inhibition of Bovine Hepatic Cytochrome P450 by 43 Commercial Bovine Medicines Using a Combination of In Vitro Assays and Pharmacokinetic Data from the Literature. Drug Metab Lett. 2019;13(2):123-131. doi: 10.2174/1872312813666191120094649. PMID: 31750810.
6: Baĭrakova L. Prouchvaniia vurkhu razpredelenieto i zadurzhaneto na nitroksinil v tukani i technosti na edri i drebni prezhivni zhivotni, tretirani s fastsiolid [Distribution and retention of nitroxinil in the tissues and fluids of large and small ruminants treated with fasciolide]. Vet Med Nauki. 1979;16(5):18-22. Bulgarian. PMID: 545838.
7: Na G, Hu X, Yang J, Sun Y, Kwee S, Tang L, Xing G, Xing Y, Zhang G. A rapid colloidal gold-based immunochromatographic strip assay for monitoring nitroxynil in milk. J Sci Food Agric. 2020 Mar 30;100(5):1860-1866. doi: 10.1002/jsfa.10074. Epub 2020 Jan 20. PMID: 31602650.
8: Maffei Facino R, Pitrè D, Carini M. The reductive metabolism of the nitroaromatic flukicidal agent nitroxinil by liver microsomal cytochrome P-450. Farmaco Sci. 1982 Jul;37(7):463-74. PMID: 7128805.
9: Romero J, Villaguala C, Quiroz F, Landaeta-Aqueveque C, Alfaro G, Pérez R. Flukicide efficacy against Fasciola hepatica of Triclabendazole and Nitroxynil in cattle of the central valley of Chile. Rev Bras Parasitol Vet. 2019 Jan- Mar;28(1):164-167. doi: 10.1590/S1984-296120180089. Epub 2019 Mar 11. PMID: 30892461.
10: Maffei Facino R, Carini M, Aldini G, Ceserani R, Casciarri I, Cavalletti E, Verderio L. Efficacy of glutathione for treatment of fascioliasis. An investigation in the experimentally infested rat. Arzneimittelforschung. 1993 Apr;43(4):455-60. PMID: 8494576.
