MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 413895 | Name: Propiomazine maleate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propiomazine is a phenothiazine derivative primarily used as a sedative and antihistamine. It exhibits potent antagonistic activity at histamine H1 receptors (Ki ~2.3 nM), contributing to its sedative and anti-allergic effects. Additionally, Propiomazine has moderate affinity for several other receptors, including dopamine D2 (Ki ~160 nM), serotonin 5-HT2A (Ki ~67 nM), and muscarinic acetylcholine receptors, which may explain its antipsychotic-like side effects and potential anticholinergic properties.

Chemical Structure

Propiomazine maleate
Propiomazine maleate
CAS#3568-23-8 (maleate)

Theoretical Analysis

MedKoo Cat#: 413895

Name: Propiomazine maleate

CAS#: 3568-23-8 (maleate)

Chemical Formula: C24H28N2O5S

Exact Mass: 456.1719

Molecular Weight: 456.56

Elemental Analysis: C, 63.14; H, 6.18; N, 6.14; O, 17.52; S, 7.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
3568-23-8 (maleate) 362-29-8 (free base) 1240-15-9 (HCl)
Synonym
Propiomazine maleate; Indorm; Dorevane; Propavan
IUPAC/Chemical Name
1-Propanone, 1-(10-(2-dimethylaminopropyl)-phenothiazin-2-yl)-, maleate
InChi Key
ILEKKZUHFYUQIE-BTJKTKAUSA-N
InChi Code
InChI=1S/C20H24N2OS.C4H4O4/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20;5-3(6)1-2-4(7)8/h6-12,14H,5,13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code
CCC(C(C=C1N2CC(N(C)C)C)=CC=C1SC3=C2C=CC=C3)=O.O=C(O)/C=C\C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 456.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Parodi López N, Svensson SA, Lönnbro J, Hoffmann M, Wallerstedt SM. Reliability and validity of the Swedish indicator 'Drugs that should be avoided in older people'-an appraisal of a set of potentially inappropriate medications. Eur J Clin Pharmacol. 2024 Sep;80(9):1285-1293. doi: 10.1007/s00228-024-03700-x. Epub 2024 May 14. PMID: 38743072; PMCID: PMC11303435. 2: Dahlén E, Bardage C, Tuvendal P, Ljung R. New users of anxiolytics and sedatives in Sweden-Drug type, doses, prescribers' characteristics, and psychiatric comorbidity in more than 750,000 patients. Int J Methods Psychiatr Res. 2024 Mar;33(1):e1998. doi: 10.1002/mpr.1998. PMID: 38351589; PMCID: PMC10903432. 3: Parodi López N, Svensson SA, Lönnbro J, Hoffmann M, Wallerstedt SM. Läkemedel som bör undvikas till äldre ur medicinskt perspektiv [The indicator »drugs that should be avoided in older people« from a medical perspective – an analysis with the patient in focus]. Lakartidningen. 2023 Nov 14;120:23043. Swedish. PMID: 37964762. 4: Elenstål E, Green H, Kronstrand R, Elmsjö A. Intralipid as a matrix additive for evaluating hyperlipidemic postmortem blood. J Anal Toxicol. 2023 Jul 22;47(6):529-534. doi: 10.1093/jat/bkad025. PMID: 37130054; PMCID: PMC10362951. 5: Sönnerstam E, Gustafsson M, Lövheim H. Potentially inappropriate medications in relation to length of nursing home stay among older adults. BMC Geriatr. 2022 Jan 22;22(1):70. doi: 10.1186/s12877-021-02639-3. PMID: 35065614; PMCID: PMC8783464. 6: Thunander Sundbom L, Fornstedt Wallin B, Wändel Liminga U, Nordmark Grass J, K Jönsson A, Nurminen ML. Sedativa antihistaminer – risk för allvarlig intoxikation [Sedating antihistamines - risk of severe intoxication]. Lakartidningen. 2021 Sep 30;118:21037. Swedish. PMID: 34590703. 7: Thorell K, Midlöv P, Fastbom J, Halling A. Importance of potentially inappropriate medications, number of chronic conditions and medications for the risk of hospitalisation in elderly in Sweden: a case-control study. BMJ Open. 2019 Sep 27;9(9):e029477. doi: 10.1136/bmjopen-2019-029477. PMID: 31562149; PMCID: PMC6773336. 8: Nordström P, Nordström A. Use of short-acting and long-acting hypnotics and the risk of fracture: a critical analysis of associations in a nationwide cohort. Osteoporos Int. 2019 Oct;30(10):1983-1993. doi: 10.1007/s00198-019-05085-5. Epub 2019 Jul 30. PMID: 31363793; PMCID: PMC6795622. 9: Lenander C, Bondesson Å, Viberg N, Beckman A, Midlöv P. Effects of medication reviews on use of potentially inappropriate medications in elderly patients; a cross-sectional study in Swedish primary care. BMC Health Serv Res. 2018 Aug 7;18(1):616. doi: 10.1186/s12913-018-3425-y. PMID: 30086742; PMCID: PMC6081800. 10: Kronstrand R, Forsman M, Roman M. Quantitative analysis of drugs in hair by UHPLC high resolution mass spectrometry. Forensic Sci Int. 2018 Feb;283:9-15. doi: 10.1016/j.forsciint.2017.12.001. Epub 2017 Dec 8. PMID: 29241093. 11: Axmon A, Sandberg M, Ahlström G, Midlöv P. Prescription of potentially inappropriate medications among older people with intellectual disability: a register study. BMC Pharmacol Toxicol. 2017 Oct 25;18(1):68. doi: 10.1186/s40360-017-0174-1. PMID: 29070067; PMCID: PMC5657112. 12: Lenander C, Bondesson Å, Viberg N, Jakobsson U, Beckman A, Midlöv P. Effects of an intervention (SÄKLÄK) on prescription of potentially inappropriate medication in elderly patients. Fam Pract. 2017 Apr 1;34(2):213-218. doi: 10.1093/fampra/cmw121. PMID: 27920120. 13: Jones AW, Holmgren A, Ahlner J. Post-mortem concentrations of drugs determined in femoral blood in single-drug fatalities compared with multi-drug poisoning deaths. Forensic Sci Int. 2016 Oct;267:96-103. doi: 10.1016/j.forsciint.2016.08.015. Epub 2016 Aug 12. PMID: 27591717. 14: Peng L, Liao B, Zhu W, Li Z, Li K. Predicting Drug-Target Interactions With Multi-Information Fusion. IEEE J Biomed Health Inform. 2017 Mar;21(2):561-572. doi: 10.1109/JBHI.2015.2513200. Epub 2015 Dec 30. PMID: 26731781. 15: Hovstadius B, Petersson G, Hellström L, Ericson L. Trends in inappropriate drug therapy prescription in the elderly in Sweden from 2006 to 2013: assessment using national indicators. Drugs Aging. 2014 May;31(5):379-86. doi: 10.1007/s40266-014-0165-5. PMID: 24687310; PMCID: PMC3997827. 16: Jones AW, Holmgren A, Ahlner J. Toxicology findings in suicides: concentrations of ethanol and other drugs in femoral blood in victims of hanging and poisoning in relation to age and gender of the deceased. J Forensic Leg Med. 2013 Oct;20(7):842-7. doi: 10.1016/j.jflm.2013.06.027. Epub 2013 Aug 8. PMID: 24112333. 17: Johnell K, Fastbom J. Gender and use of hypnotics or sedatives in old age: a nationwide register-based study. Int J Clin Pharm. 2011 Oct;33(5):788-93. doi: 10.1007/s11096-011-9536-8. Epub 2011 Jul 6. PMID: 21732166. 18: Jones AW, Kugelberg FC, Holmgren A, Ahlner J. Drug poisoning deaths in Sweden show a predominance of ethanol in mono-intoxications, adverse drug- alcohol interactions and poly-drug use. Forensic Sci Int. 2011 Mar 20;206(1-3):43-51. doi: 10.1016/j.forsciint.2010.06.015. Epub 2010 Jul 14. PMID: 20630671. 19: Landerholm L, Lennestål R. Behandling av sömnproblem under graviditet och amning [Treatment of sleep disorders during pregnancy and breast feeding]. Lakartidningen. 2006 Oct 4-10;103(40):3012-3; discussion 3014-6. Swedish. PMID: 17115673. 20: Persyn JT, McDonough JA, Nino JA, Dixon H, Boland EJ. Mucosal delivery of cytotoxic therapeutic agents: response of rat nasal mucosa to microencapsulated ethopropazine HCl enantiomer. J Microencapsul. 2005 Nov;22(7):737-44. doi: 10.1080/02652040500162428. PMID: 16421084.