MedKoo Cat#: 408140 | Name: VT-102 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.

Chemical Structure

VT-102 free base
VT-102 free base
CAS#1119382-90-9

Theoretical Analysis

MedKoo Cat#: 408140

Name: VT-102 free base

CAS#: 1119382-90-9

Chemical Formula: C21H20BrN5OS

Exact Mass: 469.0572

Molecular Weight: 470.39

Elemental Analysis: C, 53.62; H, 4.29; Br, 16.99; N, 14.89; O, 3.40; S, 6.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
VT-102 free base; VT-102; VT102; VT 102;
IUPAC/Chemical Name
3-(4-bromophenyl)-2-(dimethylamino)-N-(1-(pyridin-2-yl)ethyl)-3H-thieno[2,3-d]imidazole-5-carboxamide
InChi Key
GEZFEGZKOFUYHY-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H20BrN5OS/c1-13(16-6-4-5-11-23-16)24-19(28)18-12-17-20(29-18)27(21(25-17)26(2)3)15-9-7-14(22)8-10-15/h4-13H,1-3H3,(H,24,28)
SMILES Code
CC(C1=NC=CC=C1)NC(C2=CC3=C(S2)N(C(N(C)C)=N3)C4=CC=C(C=C4)Br)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 470.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Tang TT, Konradi AW, Feng Y, Peng X, Ma M, Li J, Yu FX, Guan KL, Post L. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Apr 13:molcanther.0717.2020. doi: 10.1158/1535-7163.MCT-20-0717. Epub ahead of print. PMID: 33850002.