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MedKoo Cat#: 573521 | Name: 217-AO

Description:

WARNING: This product is for research use only, not for human or veterinary use.

217-AO is the tertiary analogue of Phospholine --- a quaternary cholinesterase inhibitor.

Chemical Structure

217-AO
217-AO
CAS#470-94-0

Theoretical Analysis

MedKoo Cat#: 573521

Name: 217-AO

CAS#: 470-94-0

Chemical Formula: C10H22NO7PS

Exact Mass: 331.0855

Molecular Weight: 331.32

Elemental Analysis: C, 36.25; H, 6.69; N, 4.23; O, 33.80; P, 9.35; S, 9.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
217-AO, AO 217
IUPAC/Chemical Name
Diethoxy-(2-dimethylaminoethylthio)phosphine oxide oxalate
InChi Key
PXPPTYPWWLDKPW-UHFFFAOYSA-N
InChi Code
1S/C8H20NO3PS.C2H2O4/c1-5-11-13(10,12-6-2)14-8-7-9(3)4;3-1(4)2(5)6/h5-8H2,1-4H3;(H,3,4)(H,5,6)
SMILES Code
P(=O)(SCCN(C)C)(OCC)OCC.C(=O)(O)C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 331.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Brimijoin S, Skau K, Wiermaa MJ. On the origin and fate of external acetylcholinesterase in peripheral nerve. J Physiol. 1978 Dec;285:143-58. PubMed PMID: 84869; PubMed Central PMCID: PMC1281748. 2: Faff J, Rabsztyn T, Rump S. The effects of fluostigmine, phospholine and compound 217 AO on abnormalities of muscle action potentials caused by complete inhibition of acetylcholinesterase. Acta Physiol Pol. 1975 Mar-Apr;26(2):197-204. PubMed PMID: 167546. 3: SCHAUMANN W, JOB C. Differential effects of a quaternary cholinesterase inhibitor, phospholine, and its tertiary analogue, compound 217-AO, on central control of respiration and on neuromuscular transmission: the antagonism by 217-AO of the respiratory arrest caused by morphine. J Pharmacol Exp Ther. 1958 Jun;123(2):114-20. PubMed PMID: 13550065.

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RSU 1150

RSU 1150