MedKoo Cat#: 576628 | Name: Imipramine maleate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Imipramine maleate is a tricyclic antidepressant (TCA) of the dibenzazepine group.

Chemical Structure

Imipramine maleate
Imipramine maleate
CAS#93980-91-7

Theoretical Analysis

MedKoo Cat#: 576628

Name: Imipramine maleate

CAS#: 93980-91-7

Chemical Formula: C23H28N2O4

Exact Mass: 396.2049

Molecular Weight: 396.49

Elemental Analysis: C, 69.68; H, 7.12; N, 7.07; O, 16.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Imipramine maleate
IUPAC/Chemical Name
(10,11-Dihydro-5H-dibenz(b,f)azepine-5-propyl)dimethylammonium hydrogen maleate
InChi Key
LQGZMKDJRWNKAR-BTJKTKAUSA-N
InChi Code
InChI=1S/C19H24N2.C4H4O4/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;5-3(6)1-2-4(7)8/h3-6,8-11H,7,12-15H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code
CN(C)CCCN1c2ccccc2CCc3ccccc13.OC(=O)\C=C/C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 396.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hearn L, Derry S, Phillips T, Moore RA, Wiffen PJ. Imipramine for neuropathic pain in adults. Cochrane Database Syst Rev. 2014 May 19;5:CD010769. doi: 10.1002/14651858.CD010769.pub2. Review. PubMed PMID: 24838845. 2: D'Agostino ML, Risser J, Robinson-Bostom L. Imipramine-induced hyperpigmentation: a case report and review of the literature. J Cutan Pathol. 2009 Jul;36(7):799-803. doi: 10.1111/j.1600-0560.2008.01121.x. Review. PubMed PMID: 19519613. 3: Dean CE, Grund FM. Imipramine-associated hyperpigmentation. Ann Pharmacother. 2003 Jun;37(6):825-8. Review. PubMed PMID: 12773071. 4: Hunsballe JM, Djurhuus JC. Clinical options for imipramine in the management of urinary incontinence. Urol Res. 2001 Apr;29(2):118-25. Review. PubMed PMID: 11396729. 5: Barros HM, Ferigolo M. Ethopharmacology of imipramine in the forced-swimming test: gender differences. Neurosci Biobehav Rev. 1998;23(2):279-86. Review. PubMed PMID: 9884121. 6: Yasuda K. [Tricyclic antidepressants (imipramine, desipramine, amitriptyline, nortriptyline)]. Nihon Rinsho. 1995 Feb;53 Su Pt 1:934-7. Review. Japanese. PubMed PMID: 8753592. 7: Ferguson KL. Imipramine-provoked paradoxical pheochromocytoma crisis: a case of cardiogenic shock. Am J Emerg Med. 1994 Mar;12(2):190-2. Review. PubMed PMID: 8161395. 8: Parsons B, Quitkin FM, McGrath PJ, Stewart JW, Tricamo E, Ocepek-Welikson K, Harrison W, Rabkin JG, Wager SG, Nunes E. Phenelzine, imipramine, and placebo in borderline patients meeting criteria for atypical depression. Psychopharmacol Bull. 1989;25(4):524-34. Review. PubMed PMID: 2698483. 9: Mavissakalian M. Differential effects of imipramine and behavior therapy on panic disorder with agoraphobia. Psychopharmacol Bull. 1989;25(1):27-9. Review. PubMed PMID: 2672069. 10: Hrdina PD. Imipramine binding sites in brain and platelets: role in affective disorders. Int J Clin Pharmacol Res. 1989;9(2):119-22. Review. PubMed PMID: 2541089. 11: Plenge P, Mellerup ET, Gjerris A. Imipramine binding in depressive patients diagnosed according to different criteria. Acta Psychiatr Scand. 1988 Aug;78(2):156-61. Review. PubMed PMID: 2851919. 12: Bech P, Eplov L, Gastpar M, Gentsch C, Mendlewicz J, Plenge P, Rielaert C, Mellerup ET. WHO pilot study on the validity of imipramine platelet receptor binding sites as a biological marker of endogenous depression. A preliminary report on the initial evaluation phase of a World Health Organization Collaborative Study. Pharmacopsychiatry. 1988 May;21(3):147-50. Review. PubMed PMID: 2841696. 13: Gram LF. Imipramine: a model substance in pharmacokinetic research. Acta Psychiatr Scand Suppl. 1988;345:81-4. Review. PubMed PMID: 3067542. 14: Mellerup ET, Plenge P. Imipramine binding in depression and other psychiatric conditions. Acta Psychiatr Scand Suppl. 1988;345:61-8. Review. PubMed PMID: 2852451. 15: Boschmans SA, Perkin MF, Terblanche SE. Antidepressant drugs: imipramine, mianserin and trazodone. Comp Biochem Physiol C. 1987;86(2):225-32. Review. PubMed PMID: 2882911. 16: Asberg M, Wägner A. Biochemical effects of antidepressant treatment--studies of monoamine metabolites in cerebrospinal fluid and platelet [3H]imipramine binding. Ciba Found Symp. 1986;123:57-83. Review. PubMed PMID: 2434288. 17: Kane JM, Lieberman J. The efficacy of amoxapine, maprotiline, and trazodone in comparison to imipramine and amitriptyline: a review of the literature. Psychopharmacol Bull. 1984 Spring;20(2):240-9. Review. PubMed PMID: 6374720. 18: Langer SZ, Raisman R. Binding of [3H]imipramine and [3H]desipramine as biochemical tools for studies in depression. Neuropharmacology. 1983 Mar;22(3 Spec No):407-13. Review. PubMed PMID: 6304558. 19: Langer SZ, Zarifian E, Briley M, Raisman R, Sechter D. High-affinity 3H-imipramine binding: a new biological marker in depression. Pharmacopsychiatria. 1982 Jan;15(1):4-10. Review. PubMed PMID: 7038720. 20: Rogers SC, Clay PM. A statistical review of controlled trials of imipramine and placebo in the treatment of depressive illnesses. Br J Psychiatry. 1975 Dec;127:599-603. Review. PubMed PMID: 1104034.