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MedKoo Cat#: 591795 | Name: Mansonone E

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mansonone E inhibits topoisomerase II. It has cytotoxic and topo inhibitory potencies.

Chemical Structure

Mansonone E
Mansonone E
CAS#5090-87-9

Theoretical Analysis

MedKoo Cat#: 591795

Name: Mansonone E

CAS#: 5090-87-9

Chemical Formula: C15H14O3

Exact Mass: 242.9430

Molecular Weight: 242.27

Elemental Analysis: C, 74.36; H, 5.82; O, 19.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Mansonone E;
IUPAC/Chemical Name
3,6,9-trimethyl-2,3-dihydrobenzo[de]chromene-7,8-dione
InChi Key
SYWTYRLIJCHSLJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14O3/c1-7-4-5-10-8(2)6-18-15-9(3)13(16)14(17)11(7)12(10)15/h4-5,8H,6H2,1-3H3
SMILES Code
O=C1C2=C3C(C(C)COC3=C(C)C1=O)=CC=C2C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 242.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nishina A, Miura A, Goto M, Terakado K, Sato D, Kimura H, Hirai Y, Sato H, Phay N. Mansonone E from Mansonia gagei Inhibited α-MSH-Induced Melanogenesis in B16 Cells by Inhibiting CREB Expression and Phosphorylation in the PI3K/Akt Pathway. Biol Pharm Bull. 2018;41(5):770-776. doi: 10.1248/bpb.b17-01045. PubMed PMID: 29709914. 2: Mahalapbutr P, Nutho B, Wolschann P, Chavasiri W, Kungwan N, Rungrotmongkol T. Molecular insights into inclusion complexes of mansonone E and H enantiomers with various β-cyclodextrins. J Mol Graph Model. 2018 Jan;79:72-80. doi: 10.1016/j.jmgm.2017.11.006. Epub 2017 Nov 11. PubMed PMID: 29154164. 3: Huang ZH, Zhuo ST, Li CY, Xie HT, Li D, Tan JH, Ou TM, Huang ZS, Gu LQ, Huang SL. Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors. Eur J Med Chem. 2013 Oct;68:58-71. doi: 10.1016/j.ejmech.2013.07.011. Epub 2013 Aug 1. PubMed PMID: 23968711. 4: Changwong N, Sabphon C, Ingkaninan K, Sawasdee P. Acetyl- and butyryl-cholinesterase inhibitory activities of mansorins and mansonones. Phytother Res. 2012 Mar;26(3):392-6. doi: 10.1002/ptr.3576. Epub 2011 Jul 21. PubMed PMID: 21780212. 5: Boonsri S, Karalai C, Ponglimanont C, Chantrapromma S, Kanjana-Opas A. Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. J Nat Prod. 2008 Jul;71(7):1173-7. doi: 10.1021/np800055q. Epub 2008 Jun 14. PubMed PMID: 18553924. 6: Puckhaber LS, Stipanovic RD. Thespesenone and dehydrooxoperezinone-6-methyl ether, new sesquiterpene quinones from Thespesia populnea. J Nat Prod. 2004 Sep;67(9):1571-3. PubMed PMID: 15387662. 7: Wang D, Xia M, Cui Z, Tashiro S, Onodera S, Ikejima T. Cytotoxic effects of mansonone E and F isolated from Ulmus pumila. Biol Pharm Bull. 2004 Jul;27(7):1025-30. PubMed PMID: 15256734. 8: Tiew P, Ioset JR, Kokpol U, Chavasiri W, Hostettmann K. Antifungal, antioxidant and larvicidal activities of compounds isolated from the heartwood of Mansonia gagei. Phytother Res. 2003 Feb;17(2):190-3. PubMed PMID: 12601687. 9: Nambiar MP, Murugesan R, Wu HC. Inhibition of the cytotoxicity of protein toxins by a novel plant metabolite, mansonone-D. J Cell Physiol. 1998 Jul;176(1):40-9. PubMed PMID: 9618143. 10: Villamil SH, Dubin M, Portela MP, Perissinotti LJ, Brusa MA, Stoppani AO. Semiquinone production by lipophilic o-naphthoquinones. Redox Rep. 1997 Aug;3(4):245-52. doi: 10.1080/13510002.1997.11747117. PubMed PMID: 27415027. 11: Villamil SF, Dubin M, Galeffi C, Stoppani AO. Effects of mansonones on lipid peroxidation, P450 monooxygenase activity, and superoxide anion generation by rat liver microsomes. Biochem Pharmacol. 1990 Nov 15;40(10):2343-51. PubMed PMID: 2173928.

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