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MedKoo Cat#: 464576 | Name: CHEMBL94431

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CHEMBL94431 is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase.

Chemical Structure

CHEMBL94431
CHEMBL94431
CAS#202475-55-6

Theoretical Analysis

MedKoo Cat#: 464576

Name: CHEMBL94431

CAS#: 202475-55-6

Chemical Formula: C16H14FN3O2

Exact Mass: 299.1070

Molecular Weight: 299.31

Elemental Analysis: C, 64.21; H, 4.71; F, 6.35; N, 14.04; O, 10.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
CHEMBL94431; CHEMBL 94431; CHEMBL-94431; PD153035 Analog 30; PD 153035 Analog 30; PD-153035 Analog 30;
IUPAC/Chemical Name
N-(3-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
InChi Key
DFWBDVRBHHFDNZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H14FN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
SMILES Code
COC1=CC2=NC=NC(NC3=CC=CC(F)=C3)=C2C=C1OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 299.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tsai YT, Chang CM, Wang JY, Hou MF, Wang JM, Shiurba R, Chang WC, Chang WC. Function of DNA methyltransferase 3a in lead (Pb(2+) )-Induced Cyclooxygenase-2 gene. Environ Toxicol. 2015 Sep;30(9):1024-32. doi: 10.1002/tox.21976. Epub 2014 Mar 17. PMID: 24639330. 2: Wan YS, Wang ZQ, Voorhees J, Fisher G. EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes. Cell Signal. 2001 Feb;13(2):139-44. doi: 10.1016/s0898-6568(00)00146-7. PMID: 11257459.

View History

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