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MedKoo Cat#: 524684 | Name: CHF-1024

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CHF-1024 is a novel and selective D2-dopaminergic/alpha2-adrenoceptor receptor agonist. CHF-1024 has an antiarrhythmic effect.

Chemical Structure

CHF-1024
CHF-1024
CAS#90060-20-1

Theoretical Analysis

MedKoo Cat#: 524684

Name: CHF-1024

CAS#: 90060-20-1

Chemical Formula: C11H16ClNO2

Exact Mass:

Molecular Weight: 229.70

Elemental Analysis: C, 57.52; H, 7.02; Cl, 15.43; N, 6.10; O, 13.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CHF-1024; CHF 1024; CHF1024; UNII-HPH2L3QA2F.
IUPAC/Chemical Name
1,2-Naphthalenediol, 5,6,7,8-tetrahydro-6-(methylamino)-, hydrochloride
InChi Key
MIMDMPWWTWVHFK-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H15NO2.ClH/c1-12-8-3-4-9-7(6-8)2-5-10(13)11(9)14;/h2,5,8,12-14H,3-4,6H2,1H3;1H
SMILES Code
CNC1CCc2c(ccc(c2O)O)C1.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 229.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fiordaliso F, De Angelis N, Bai A, Cuccovillo I, Salio M, Serra DM, Bianchi R, Razzetti R, Latini R, Masson S. Effect of beta-adrenergic and renin-angiotensin system blockade on myocyte apoptosis and oxidative stress in diabetic hypertensive rats. Life Sci. 2007 Sep 1;81(12):951-9. Epub 2007 Jun 21. PubMed PMID: 17825849. 2: Berni R, Cacciani F, Zaniboni M, Savi M, Bocchi L, Lapucci S, Razzetti R, Pastore F, Musso E, Stilli D. Effects of the alpha2-adrenergic/DA2-dopaminergic agonist CHF-1024 in preventing ventricular arrhythmogenesis and myocyte electrical remodeling, in a rat model of pressure-overload cardiac hypertrophy. J Cardiovasc Pharmacol. 2006 Feb;47(2):295-302. PubMed PMID: 16495769. 3: Rossoni G, Manfredi B, Cavalca V, Razzetti R, Bongrani S, Polvani GL, Berti F. The aminotetraline derivative (+/-)-(R,S)-5,6-dihydroxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene hydrochloride (CHF-1024) displays cardioprotection in postischemic ventricular dysfunction of the rat heart. J Pharmacol Exp Ther. 2003 Nov;307(2):633-9. Epub 2003 Sep 15. PubMed PMID: 12975493. 4: Savolainen J, Rautio J, Razzetti R, Järvinen T. A novel D2-dopaminergic and alpha2-adrenoceptor receptor agonist induces substantial and prolonged IOP decrease in normotensive rabbits. J Pharm Pharmacol. 2003 Jun;55(6):789-94. PubMed PMID: 12841939. 5: Masson S, Chimenti S, Salio M, Torri M, Limana F, Bernasconi R, Calvillo L, Santambrogio D, Gagliano N, Arosio B, Annoni G, Razzetti R, Bongrani S, Latini R. CHF-1024, a DA2/alpha2 agonist, blunts norepinephrine excretion and cardiac fibrosis in pressure overload. Cardiovasc Drugs Ther. 2001 Mar;15(2):131-8. PubMed PMID: 11669406. 6: Masson S, Masseroli M, Fiordaliso F, Calvillo L, D'Aquila S, Bernasconi R, Garrido G, Torri M, Razzetti R, Bongrani S, Latini R. Effects of a DA2/alpha2 agonist and a beta1-blocker in combination with an ACE inhibitor on adrenergic activity and left ventricular remodeling in an experimental model of left ventricular dysfunction after coronary artery occlusion. J Cardiovasc Pharmacol. 1999 Sep;34(3):321-6. PubMed PMID: 10470987. 7: Latini R, Masson S, Jeremic G, Luvarà G, Fiordaliso F, Calvillo L, Bernasconi R, Torri M, Rondelli I, Razzetti R, Bongrani S. Comparative efficacy of a DA2/alpha2 agonist and a beta-blocker in reducing adrenergic drive and cardiac fibrosis in an experimental model of left ventricular dysfunction after coronary artery occlusion. J Cardiovasc Pharmacol. 1998 Apr;31(4):601-8. PubMed PMID: 9554811.

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