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MedKoo Cat#: 413869 | Name: Doxycycline fosfatex

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Doxycycline is a synthetic tetracycline derivative with similar antimicrobial activity. Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Doxycycline has bacteriostatic activity against a broad range of Gram-positive and Gramnegative bacteria. Doxycycline has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections.

Chemical Structure

Doxycycline fosfatex
Doxycycline fosfatex
CAS#83038-87-3 (fosfatex)

Theoretical Analysis

MedKoo Cat#: 413869

Name: Doxycycline fosfatex

CAS#: 83038-87-3 (fosfatex)

Chemical Formula: C66H76N6NaO36P4+

Exact Mass: 1675.3143

Molecular Weight: 1676.22

Elemental Analysis: C, 47.29; H, 4.57; N, 5.01; Na, 1.37; O, 34.36; P, 7.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
17086-28-1 (hydrate) 564-25-0 (free) 83038-87-3 (fosfatex) 24390-14-5 (hyclate) 10592-13-9 (HCl)
Synonym
Doxycycline fosfatex; AB08; DMSC
IUPAC/Chemical Name
(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide, compound with sodium trihydrogen metaphosphate (H3NaP4O12) (3:1)
InChi Key
QIQLSEYJTHQCRU-JJBWZFNDSA-N
InChi Code
InChI=1S/3C22H24N2O8.Na.H4O12P4/c3*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;;1-13(2)9-14(3,4)11-16(7,8)12-15(5,6)10-13/h3*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);;(H,1,2)(H,3,4)(H,5,6)(H,7,8)/q;;;+1;/t3*7-,10+,14+,15-,17-,22-;;/m000../s1
SMILES Code
C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(O)=C(C([C@]3(C(O)=C2C(c4c1cccc4O)=O)O)=O)C(N)=O)N(C)C)O.C[C@@H]5[C@H]6[C@@H]([C@H]7[C@@H](C(O)=C(C([C@]7(C(O)=C6C(c8c5cccc8O)=O)O)=O)C(N)=O)N(C)C)O.C[C@@H]9[C@H]%10[C@@H]([C@H]%11[C@@H](C(O)=C(C([C@]%11(C(O)=C%10C(c%12c9cccc%12O)=O)O)=O)C(N)=O)N(C)C)O.OP%13(OP(O)(OP(O)(OP(O)(O%13)=O)=O)=O)=O.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,676.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Use of oral tetracyclines in the treatment of adult outpatients with skin and skin structure infections: Focus on doxycycline, minocycline, and omadacycline. Pharmacotherapy. 2021 Nov;41(11):915-931. doi: 10.1002/phar.2625. Epub 2021 Oct 5. PMID: 34558677. 5: Patel RS, Parmar M. Doxycycline Hyclate. 2021 Aug 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 32310348. 6: Zhao J, Zou Y, Li K, Huang X, Niu C, Wang Z, Zhao S, Zhang Y, Song C, Xie Y. Doxycycline and minocycline in Helicobacter pylori treatment: A systematic review and meta-analysis. Helicobacter. 2021 Oct;26(5):e12839. doi: 10.1111/hel.12839. Epub 2021 Jul 28. PMID: 34318971. 7: Paghdar S, Khan TM, Patel NP, Chandrasekaran S, De Sousa JFM, Tsouklidis N. Doxycycline Therapy for Abdominal Aortic Aneurysm: Inhibitory Effect on Matrix Metalloproteinases. Cureus. 2021 May 11;13(5):e14966. doi: 10.7759/cureus.14966. PMID: 34123662; PMCID: PMC8191685. 8: Manna S, Bageac DV, Berenstein A, Sinclair CF, Kirke D, De Leacy R. Bleomycin sclerotherapy following doxycycline lavage in the treatment of ranulas: A retrospective analysis and review of the literature. Neuroradiol J. 2021 Oct;34(5):449-455. doi: 10.1177/19714009211008790. Epub 2021 Apr 8. PMID: 33832375; PMCID: PMC8559021. 9: Campetti D, Kelly A, Diaz K. Doxycycline-induced idiopathic intracranial hypertension in a patient with Lyme disease. JAAPA. 2021 Mar 1;34(3):35-37. doi: 10.1097/01.JAA.0000731504.17394.29. PMID: 33600108. 10: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Doxycycline. 2021 Jan 18. PMID: 29999621. 11: Narendrakumar L, Joseph I, Thomas S. Potential effectiveness and adverse implications of repurposing doxycycline in COVID-19 treatment. Expert Rev Anti Infect Ther. 2021 Aug;19(8):1001-1008. doi: 10.1080/14787210.2021.1865803. Epub 2020 Dec 24. PMID: 33322952. 12: Nath S, Pulikkotil SJ, Dharmarajan L, Arunachalam M, Jing KT. Effect of locally delivered doxycycline as an adjunct to scaling and root planing in the treatment of periodontitis in smokers: A systematic review of randomized controlled trials with meta-analysis and trial sequential analysis. Dent Res J (Isfahan). 2020 Aug 14;17(4):235-243. PMID: 33282148; PMCID: PMC7688043. 13: Nykytyuk S, Boyarchuk O, Klymnyuk S, Levenets S. The Jarisch-Herxheimer reaction associated with doxycycline in a patient with Lyme arthritis. Reumatologia. 2020;58(5):335-338. doi: 10.5114/reum.2020.99143. Epub 2020 Oct 3. PMID: 33227092; PMCID: PMC7667941. 14: Amores-Martín E, Melé-Ninot G, Del Alcázar Viladomiu E, Fernández-Figueras MT. Successful Treatment of White Sponge Nevus With Oral Doxycycline: A Case Report and Review of the Literature. Actas Dermosifiliogr (Engl Ed). 2021 May;112(5):463-466. English, Spanish. doi: 10.1016/j.ad.2019.10.009. Epub 2020 Nov 18. PMID: 33220312. 15: Yates PA, Newman SA, Oshry LJ, Glassman RH, Leone AM, Reichel E. Doxycycline treatment of high-risk COVID-19-positive patients with comorbid pulmonary disease. Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620951053. doi: 10.1177/1753466620951053. PMID: 32873175; PMCID: PMC7476338. 16: Hadjimichael AC, Foukas AF, Savvidou OD, Mavrogenis AF, Psyrri AK, Papagelopoulos PJ. The anti-neoplastic effect of doxycycline in osteosarcoma as a metalloproteinase (MMP) inhibitor: a systematic review. Clin Sarcoma Res. 2020 Apr 30;10:7. doi: 10.1186/s13569-020-00128-6. PMID: 32377334; PMCID: PMC7193389. 17: Lees KA, Orlandi RR, Oakley G, Alt JA. The Role of Macrolides and Doxycycline in Chronic Rhinosinusitis. Immunol Allergy Clin North Am. 2020 May;40(2):303-315. doi: 10.1016/j.iac.2019.12.005. Epub 2020 Jan 18. PMID: 32278453. 18: Clemens DL, Duryee MJ, Hall JH, Thiele GM, Mikuls TR, Klassen LW, Zimmerman MC, Anderson DR. Relevance of the antioxidant properties of methotrexate and doxycycline to their treatment of cardiovascular disease. Pharmacol Ther. 2020 Jan;205:107413. doi: 10.1016/j.pharmthera.2019.107413. Epub 2019 Oct 15. PMID: 31626869. 19: Wangrangsimakul T, Phuklia W, Newton PN, Richards AL, Day NPJ. Scrub Typhus and the Misconception of Doxycycline Resistance. Clin Infect Dis. 2020 May 23;70(11):2444-2449. doi: 10.1093/cid/ciz972. PMID: 31570937; PMCID: PMC7245148. 20: Grant JS, Stafylis C, Celum C, Grennan T, Haire B, Kaldor J, Luetkemeyer AF, Saunders JM, Molina JM, Klausner JD. Doxycycline Prophylaxis for Bacterial Sexually Transmitted Infections. Clin Infect Dis. 2020 Mar 3;70(6):1247-1253. doi: 10.1093/cid/ciz866. PMID: 31504345; PMCID: PMC7319058.