Synonym
Dmp 811; Dmp811; Dmp-811
IUPAC/Chemical Name
1H-Imidazole-5-carboxylic acid, 4-ethyl-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
InChi Key
OFYWYKMCRWMPPQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H24N6O2/c1-3-7-20-24-19(4-2)21(23(30)31)29(20)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-25-27-28-26-22/h5-6,8-13H,3-4,7,14H2,1-2H3,(H,30,31)(H,25,26,27,28)
SMILES Code
O=C(C1=C(CC)N=C(CCC)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
416.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wong PC, Huang SM, Ardecky RJ, Carini DJ, Chiu AT, Price WA Jr, Agra AM, Wexler RR, Timmermans PB. Pharmacology and pharmacokinetics of a novel nonpeptide angiotensin II receptor antagonist--DMP 811. Clin Exp Hypertens. 1995 Nov;17(8):1233-56. doi: 10.3109/10641969509037406. PMID: 8563699.
2: Zhang KE, Vyas KP. Disposition of DMP 811 (L-708,404), a potent angiotensin II receptor antagonist, in the rat, monkey, and chimpanzee. Drug Metab Dispos. 1995 Oct;23(10):1104-9. PMID: 8654199.
3: Aungst BJ, Blake JA, Rogers NJ, Saitoh H, Hussain MA, Ensinger CL, Pruitt JR. Prodrugs to improve the oral bioavailability of a diacidic nonpeptide angiotensin II antagonist. Pharm Res. 1995 May;12(5):763-7. doi: 10.1023/a:1016228129729. PMID: 7479565.
4: Agra AM, Huang SM. High-performance liquid chromatographic determination of a potent AII receptor antagonist (DMP 811) in plasma. J Chromatogr. 1993 Oct 29;620(2):205-9. doi: 10.1016/0378-4347(93)80005-o. PMID: 8300787.
5: Chen X, Cui Z, Zhang F, Chang W, Chen L, Liu L. Angiotensin II and cAMP regulate AT(1)-mRNA expression in rat cardiomyocytes by transcriptional mechanism. Eur J Pharmacol. 2002 Jul 12;448(1):1-9. doi: 10.1016/s0014-2999(02)01900-3. PMID: 12126964.
6: Cui Z, Chen X, Chen L, Wang M, Liu L. [Angiotensin II regulates the expression of collagens in rat heart]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1999 Dec;21(6):483-7. Chinese. PMID: 12567498.
