MedKoo Cat#: 208007 | Name: SBP-3264

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SBP-3264 is a novel inhibitor of serine/threonine-protein kinases 3 and 4 (STK3 and STK4), specifically inhibiting the Hippo signaling pathway in cultured mammalian cells and possessing favorable pharmacokinetic and pharmacodynamic properties in mice.

Chemical Structure

SBP-3264
SBP-3264
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208007

Name: SBP-3264

CAS#: N/A

Chemical Formula: C19H20ClN5O

Exact Mass: 369.1356

Molecular Weight: 369.85

Elemental Analysis: C, 61.70; H, 5.45; Cl, 9.58; N, 18.94; O, 4.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SBP-3264; SBP3264; SBP 3264
IUPAC/Chemical Name
N-(4-(5-(3-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexyl)acetamide
InChi Key
AYRVYPOFYQSRNH-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20ClN5O/c1-12(26)24-15-5-7-25(8-6-15)19-17-16(10-21-18(17)22-11-23-19)13-3-2-4-14(20)9-13/h2-4,9-11,15H,5-8H2,1H3,(H,24,26)(H,21,22,23)
SMILES Code
ClC1=CC(C2=CNC3=C2C(N4CCC(NC(C)=O)CC4)=NC=N3)=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 369.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Bata N, Chaikuad A, Bakas NA, Limpert AS, Lambert LJ, Sheffler DJ, Berger LM, Liu G, Yuan C, Wang L, Peng Y, Dong J, Celeridad M, Layng F, Knapp S, Cosford NDP. Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2022 Jan 27;65(2):1352-1369. doi: 10.1021/acs.jmedchem.1c00804. Epub 2021 Nov 22. PMID: 34807584.