MedKoo Cat#: 464564 | Name: PTK-SMA1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PTK-SMA1 is a unique promoter of SMN2 exon 7 splicing, acting by directly stimulating splicing of exon 7.

Chemical Structure

PTK-SMA1
PTK-SMA1
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464564

Name: PTK-SMA1

CAS#: unknown

Chemical Formula: C33H37N3O8

Exact Mass: 603.2581

Molecular Weight: 603.67

Elemental Analysis: C, 65.66; H, 6.18; N, 6.96; O, 21.20

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Related CAS #
No Data
Synonym
PTK-SMA1; PTK SMA1; PTKSMA1;
IUPAC/Chemical Name
3-((6aS,10S,10aS,11aR)-8-acetyl-10-(dimethylamino)-4,6,6a,9-tetrahydroxy-5,7-dioxo-5,6a,7,10,10a,11,11a,12-octahydrotetracen-1-yl)-N-(2-(dimethylamino)ethyl)benzamide
InChi Key
XMPRUTMMSAMKDI-ZFMGIHGMSA-N
InChi Code
InChI=1S/C33H37N3O8/c1-16(37)24-29(40)27(36(4)5)22-15-19-14-21-20(17-7-6-8-18(13-17)32(43)34-11-12-35(2)3)9-10-23(38)26(21)28(39)25(19)31(42)33(22,44)30(24)41/h6-10,13,19,22,27,38,40,42,44H,11-12,14-15H2,1-5H3,(H,34,43)/t19-,22-,27-,33+/m0/s1
SMILES Code
O=C(NCCN(C)C)C1=CC=CC(C2=CC=C(O)C3=C2C[C@]4([H])C(C3=O)=C(O)[C@@](C(C(C(C)=O)=C(O)[C@H]5N(C)C)=O)(O)[C@@]5([H])C4)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 603.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hastings ML, Berniac J, Liu YH, Abato P, Jodelka FM, Barthel L, Kumar S, Dudley C, Nelson M, Larson K, Edmonds J, Bowser T, Draper M, Higgins P, Krainer AR. Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Sci Transl Med. 2009 Nov 4;1(5):5ra12. doi: 10.1126/scitranslmed.3000208. PMID: 20161659; PMCID: PMC2818805.