Synonym
Edetate disodium; Disodium edetate; Endrate; Disodium EDTA dihydrate
IUPAC/Chemical Name
sodium 2,2'-(ethane-1,2-diylbis((carboxymethyl)azanediyl))diacetate dihydrate
InChi Key
OVBJJZOQPCKUOR-UHFFFAOYSA-L
InChi Code
InChI=1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2
SMILES Code
O=C([O-])CN(CC([O-])=O)CCN(CC(O)=O)CC(O)=O.[H]O[H].[H]O[H].[Na+].[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
372.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Alam ZH, Ujueta F, Arenas IA, Nigra AE, Navas-Acien A, Lamas GA. Urinary Metal Levels after Repeated Edetate Disodium Infusions: Preliminary Findings. Int J Environ Res Public Health. 2020 Jun 29;17(13):4684. doi: 10.3390/ijerph17134684. PMID: 32610666; PMCID: PMC7370001.
2: Lamas GA, Issa OM. Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients. Curr Cardiol Rep. 2016 Feb;18(2):20. doi: 10.1007/s11886-015-0690-9. PMID: 26797807.
3: Yarbrough M, Hodge T, Menard D, Jerome R, Ryczek J, Moore D, Baldus P, Warne N, Ohtake S. Edetate Disodium as a Polysorbate Degradation and Monoclonal Antibody Oxidation Stabilizer. J Pharm Sci. 2019 Apr;108(4):1631-1635. doi: 10.1016/j.xphs.2018.11.031. Epub 2018 Nov 29. PMID: 30502482.
4: Bradberry S, Vale A. A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning. Clin Toxicol (Phila). 2009 Nov;47(9):841-58. doi: 10.3109/15563650903321064. PMID: 19852620.
5: Sultan S, Murarka S, Jahangir A, Mookadam F, Tajik AJ, Jahangir A. Chelation therapy in cardiovascular disease: an update. Expert Rev Clin Pharmacol. 2017 Aug;10(8):843-854. doi: 10.1080/17512433.2017.1339601. Epub 2017 Jun 19. PMID: 28597699.
6: Sakthithasan K, Lévy P, Poupon J, Garnier R. A comparative study of edetate calcium disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults. Clin Toxicol (Phila). 2018 Nov;56(11):1143-1149. doi: 10.1080/15563650.2018.1478424. Epub 2018 Jun 11. PMID: 29889577.
7: Fukada T, Ozaki M. Microbial growth in propofol formulations with disodium edetate and the influence of venous access system dead space. Anaesthesia. 2007 Jun;62(6):575-80. doi: 10.1111/j.1365-2044.2007.05002.x. PMID: 17506735.
8: Arenas IA, Navas-Acien A, Ergui I, Lamas GA. Enhanced vasculotoxic metal excretion in post-myocardial infarction patients following a single edetate disodium-based infusion. Environ Res. 2017 Oct;158:443-449. doi: 10.1016/j.envres.2017.06.039. Epub 2017 Jul 6. PMID: 28689036.
9: Kumar N, Soni S, Jaimini A, Ahmad FJ, Bhatnagar A, Mittal G. Edetate calcium disodium nanoparticle dry powder inhalation: a novel approach against heavy metal decorporation. Int J Pharm. 2011 Sep 15;416(1):376-83. doi: 10.1016/j.ijpharm.2011.06.038. Epub 2011 Jun 28. PMID: 21740960.
10: Chisolm JJ Jr. Mobilization of lead by calcium disodium edetate. A reappraisal. Am J Dis Child. 1987 Dec;141(12):1256-7. doi: 10.1001/archpedi.1987.04460120018020. PMID: 3120574.
