ICI-D2138 | CAS# 140841-32-3 | Biochemical

MedKoo Cat#: 576505 | Name: ICI-D2138

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-D2138 is a non-redox inhibitor of 5-lipoxygenase and leukotriene B4 synthesis.

Chemical Structure

ICI-D2138

CAS#140841-32-3

Theoretical Analysis

MedKoo Cat#: 576505

Name: ICI-D2138

CAS#: 140841-32-3

Chemical Formula: C23H24FNO4

Exact Mass: 397.1689

Molecular Weight: 397.45

Elemental Analysis: C, 69.51; H, 6.09; F, 4.78; N, 3.52; O, 16.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ICID2138; ICI D2138; ICI-D2138; ZD 2138; ZD2138; ZD-2138

IUPAC/Chemical Name

2(1H)-Quinolinone, 6-((3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy)methyl)-1-methyl-

InChi Key

SLZBEPLWGGRZAY-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H24FNO4/c1-25-21-5-3-16(11-17(21)4-6-22(25)26)15-29-20-13-18(12-19(24)14-20)23(27-2)7-9-28-10-8-23/h3-6,11-14H,7-10,15H2,1-2H3

SMILES Code

COC1(CCOCC1)c2cc(F)cc(OCc3ccc4N(C)C(=O)C=Cc4c3)c2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 397.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. McMillan RM, Spruce KE, Crawley GC, Walker ER, Foster SJ. Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. Br J Pharmacol. 1992 Dec;107(4):1042-7. doi: 10.1111/j.1476-5381.1992.tb13404.x. PMID: 1334748; PMCID: PMC1907929. 2. Crawley GC, Bird TG, Bruneau P, Dowell RI, Edwards PN, Foster SJ, Girodeau JM, McMillan RM, Walker ER, Waterson D. Structure and activity relationships leading to the discovery of ICI D2138, a selective, potent and orally active inhibitor of 5-lipoxygenase. J Lipid Mediat. 1993 Mar-Apr;6(1-3):249-57. PMID: 8395247.