GW837016X, also known as NEU-391, is a potent inhibitor of protozoan parasite proliferation. GW837016X extended life of treated mice by 50%, compared to untreated controls. At the cellular level, GW837016X inhibited mitosis and cytokinesis in T. brucei.
MedKoo Cat#: 555317
Name: GW837016X
CAS#: 833473-68-0 (free base)
Chemical Formula: C25H20ClFN4OS
Exact Mass: 478.1030
Molecular Weight: 478.97
Elemental Analysis: C, 62.69; H, 4.21; Cl, 7.40; F, 3.97; N, 11.70; O, 3.34; S, 6.69
The following data is based on the product molecular weight 478.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
