ICI-118233 | CAS# 93851-00-4 | Biochemical

MedKoo Cat#: 576490 | Name: ICI-118233

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-118233 is a selective inhibitor of dense-vesicle cyclic AMP phosphodiesterase in liver tissue.

Chemical Structure

ICI-118233

CAS#93851-00-4

Theoretical Analysis

MedKoo Cat#: 576490

Name: ICI-118233

CAS#: 93851-00-4

Chemical Formula: C12H12N4O2

Exact Mass: 244.0960

Molecular Weight: 244.25

Elemental Analysis: C, 59.01; H, 4.95; N, 22.94; O, 13.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ICI 118233; ICI118233; ICI-118233

IUPAC/Chemical Name

Urea, N-(4-(1,6-dihydro-6-oxo-3-pyridazinyl)phenyl)-N'-methyl-

InChi Key

FKWJRHATWBHIRH-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H12N4O2/c1-13-12(18)14-9-4-2-8(3-5-9)10-6-7-11(17)16-15-10/h2-7H,1H3,(H,16,17)(H2,13,14,18)

SMILES Code

CNC(=O)Nc1ccc(cc1)C2=NNC(=O)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 244.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Pyne NJ, Anderson N, Lavan BE, Milligan G, Nimmo HG, Houslay MD. Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat. Biochem J. 1987 Dec 15;248(3):897-901. doi: 10.1042/bj2480897. PMID: 2829845; PMCID: PMC1148634.