MedKoo Cat#: 561652 | Name: Tylosin tartrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tylosin tartrate is an antimicrobial for gram-positive bacteria and mycoplasma. It interferes with bacterial protein synthesis by binding to the 50S subunit.

Chemical Structure

Tylosin tartrate
Tylosin tartrate
CAS#74610-55-2

Theoretical Analysis

MedKoo Cat#: 561652

Name: Tylosin tartrate

CAS#: 74610-55-2

Chemical Formula: C50H83NO23

Exact Mass:

Molecular Weight: 1066.19

Elemental Analysis: C, 56.33; H, 7.85; N, 1.31; O, 34.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Tylosin tartrate;
IUPAC/Chemical Name
2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde (2R,3R)-tartrate salt
InChi Key
ICVKYYINQHWDLM-KBEWXLTPSA-N
InChi Code
InChI=1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1
SMILES Code
O=CC[C@@H](C[C@H]1C)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@](C)(O)C3)[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O)CC(O[C@H](CC)[C@@H](CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)/C=C(C)/C=C/C1=O)=O.O[C@H]([C@H](C(O)=O)O)C(O)=O
Appearance
Solution
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,066.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Riazuddin -, Khan S, Imtiaz N, Aslam S, Ahmad S, Khan H, Rabbani M, Muhammad J, Tanveer ZI, Ali S. Short Communication - Study on quality and efficacy of commercial tylosin and doxycycline products against local isolates of mycoplasma in broilers. Pak J Pharm Sci. 2017 Mar;30(2):541-549. PubMed PMID: 28649082. 2: Matajira CE, Moreno LZ, Gomes VT, Silva AP, Mesquita RE, Amigo CR, Christ AP, Sato MI, Moreno AM. Molecular and antimicrobial susceptibility characterization of Globicatella sulfidifaciens isolated from sow's urinary tract infection. Vet Q. 2017 Dec;37(1):48-51. doi: 10.1080/01652176.2017.1283454. PubMed PMID: 28150535. 3: Richter E, Berkner S, Ebert I, Förster B, Graf N, Herrchen M, Kühnen U, Römbke J, Simon M. Results of extended plant tests using more realistic exposure scenarios for improving environmental risk assessment of veterinary pharmaceuticals. Environ Sci Eur. 2016;28(1):22. Epub 2016 Aug 9. PubMed PMID: 27752455; PubMed Central PMCID: PMC5044973. 4: Stan GS, Badea IA, Aboul-Enein HY. HPLC Method for Quantification of Five Compounds in a Parenteral Form Used in Treatment of Companion Animals. J Chromatogr Sci. 2016 Jun 21. pii: bmw105. [Epub ahead of print] PubMed PMID: 27334291. 5: Müştak HK, Torun E, Özen D, Yücel G, Akan M, Diker KS. Effect of Lonicera japonica extract on Mycoplasma gallisepticum in naturally infected broiler flocks. Br Poult Sci. 2015;56(3):299-303. doi: 10.1080/00071668.2015.1022711. Epub 2015 Apr 10. PubMed PMID: 25731588. 6: Maxwell CL, Krehbiel CR, Wilson BK, Johnson BT, Bernhard BC, O'Neill CF, VanOverbeke DL, Mafi GG, Step DL, Richards CJ. Effects of beef production system on animal performance and carcass characteristics. J Anim Sci. 2014 Dec;92(12):5727-38. doi: 10.2527/jas.2014-7639. Epub 2014 Nov 17. PubMed PMID: 25403195. 7: Jia W, Chu X, Ling Y, Huang J, Chang J. High-throughput screening of pesticide and veterinary drug residues in baby food by liquid chromatography coupled to quadrupole Orbitrap mass spectrometry. J Chromatogr A. 2014 Jun 20;1347:122-8. doi: 10.1016/j.chroma.2014.04.081. Epub 2014 May 1. PubMed PMID: 24816507. 8: Srinivasan P, Sarmah AK, Manley-Harris M. Sorption of selected veterinary antibiotics onto dairy farming soils of contrasting nature. Sci Total Environ. 2014 Feb 15;472:695-703. doi: 10.1016/j.scitotenv.2013.11.104. Epub 2013 Dec 8. PubMed PMID: 24326064. 9: Ji LW, Dong LL, Ji H, Feng XW, Li D, Ding RL, Jiang SX. Comparative pharmacokinetics and bioavailability of tylosin tartrate and tylosin phosphate after a single oral and i.v. administration in chickens. J Vet Pharmacol Ther. 2014 Jun;37(3):312-5. doi: 10.1111/jvp.12092. Epub 2013 Dec 11. PubMed PMID: 24325541. 10: Alexander TW, Cook S, Klima CL, Topp E, McAllister TA. Susceptibility to tulathromycin in Mannheimia haemolytica isolated from feedlot cattle over a 3-year period. Front Microbiol. 2013 Oct 9;4:297. doi: 10.3389/fmicb.2013.00297. eCollection 2013. PubMed PMID: 24130555; PubMed Central PMCID: PMC3793196. 11: Eguchi K, Otawa K, Ohishi R, Nagase H, Ogata T, Nagai H, Murata N, Ishikawa H, Hirata K, Nakai Y. Establishment of evaluation method to determine effects of veterinary medicinal products on manure fermentation using small-scale composting apparatus. J Biosci Bioeng. 2012 Sep;114(3):312-7. doi: 10.1016/j.jbiosc.2012.04.001. Epub 2012 May 16. PubMed PMID: 22595343. 12: Khatiwada J, Fullerton M, Davis S, Williams LL. Antimicrobial susceptibility testing of Shiga toxin-producing Escherichia coli from various samples by using a spiral gradient endpoint technique. Foodborne Pathog Dis. 2012 Jan;9(1):20-6. doi: 10.1089/fpd.2011.0943. Epub 2011 Sep 22. PubMed PMID: 21939348. 13: Sanli S, Sanli N, Alsancak G. Spectrophotometric determination of acidity constants of some macrolides in acetonitrile-water binary mixtures. Acta Chim Slov. 2010 Dec;57(4):980-7. PubMed PMID: 24061907. 14: Scott BA, Mortensen JE, McKeever TM, Logas DB, McKeever PJ. Efficacy of tylosin tartrate on canine Staphylococcus intermedius isolates in vitro. Vet Ther. 2010 Fall;11(3):E1-7. PubMed PMID: 20960412. 15: Lilia G, Aguilera R, Cortés-Cuevas A, Rosario C, Sumano H. Circadian serum concentrations of tylosin in broilers after feed or water medication. Br Poult Sci. 2008 Sep;49(5):619-24. doi: 10.1080/00071660802357033. PubMed PMID: 18836909. 16: Velicu M, Suri R. Presence of steroid hormones and antibiotics in surface water of agricultural, suburban and mixed-use areas. Environ Monit Assess. 2009 Jul;154(1-4):349-59. doi: 10.1007/s10661-008-0402-7. Epub 2008 Jun 21. PubMed PMID: 18568409. 17: Litterio NJ, Calvinho LF, Flores MM, Tarabla HD, Boggio JC. Microbiological screening test validation for detection of tylosin excretion in milk of cows with low and high somatic cell counts. J Vet Med A Physiol Pathol Clin Med. 2007 Feb;54(1):30-5. PubMed PMID: 17359452. 18: Lizarazo YA, Ferri EF, de la Fuente AJ, Martín CB. Evaluation of changes in antimicrobial susceptibility patterns of Pasteurella multocida subsp multocida isolates from pigs in Spain in 1987-1988 and 2003-2004. Am J Vet Res. 2006 Apr;67(4):663-8. PubMed PMID: 16579760. 19: Loftin KA, Henny C, Adams CD, Surampali R, Mormile MR. Inhibition of microbial metabolism in anaerobic lagoons by selected sulfonamides, tetracyclines, lincomycin, and tylosin tartrate. Environ Toxicol Chem. 2005 Apr;24(4):782-8. PubMed PMID: 15839550. 20: Moretto A, Tesolin L, Marsilio F, Schiavon M, Berna M, Veronese FM. Slow release of two antibiotics of veterinary interest from PVA hydrogels. Farmaco. 2004 Jan;59(1):1-5. PubMed PMID: 14751309.