MedKoo Cat#: 576485 | Name: ICI-147798

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-147798 is a beta adrenoceptor antagonist.

Chemical Structure

ICI-147798
ICI-147798
CAS#83812-65-1

Theoretical Analysis

MedKoo Cat#: 576485

Name: ICI-147798

CAS#: 83812-65-1

Chemical Formula: C24H30ClN7O4

Exact Mass: 515.2048

Molecular Weight: 516.00

Elemental Analysis: C, 55.87; H, 5.86; Cl, 6.87; N, 19.00; O, 12.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ICI147798; ICI 147798; ICI-147798
IUPAC/Chemical Name
Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-(2-((2-((2-hydroxy-3-(1-naphthalenyloxy)propyl)amino)ethyl)amino)-1,1-dimethyl-2-oxoethyl)-
InChi Key
GUMKBOVHSJWJQS-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H30ClN7O4/c1-24(2,32-22(34)18-20(26)31-21(27)19(25)30-18)23(35)29-11-10-28-12-15(33)13-36-17-9-5-7-14-6-3-4-8-16(14)17/h3-9,15,28,33H,10-13H2,1-2H3,(H,29,35)(H,32,34)(H4,26,27,31)
SMILES Code
CC(C)(NC(=O)c1nc(Cl)c(N)nc1N)C(=O)NCCNCC(O)COc2cccc3ccccc23
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 516.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Doggrell SA, Surman AJ. Loss of maximum attenuation and receptor reserve for isoprenaline at the beta 2-adrenoceptors of the portal veins of hypertensive rats. J Hypertens. 1995 Sep;13(9):1023-9. doi: 10.1097/00004872-199509000-00013. PMID: 8586820. 2. Keith RA, Hwang TF, Murthy VS, Kau ST, Salama AI, Giles RE. ICI 147,798: a slowly dissociable beta adrenoceptor antagonist that causes insurmountable beta-1 and surmountable beta-2 adrenoceptor antagonism in isolated tissues. J Pharmacol Exp Ther. 1989 Jan;248(1):240-8. PMID: 2563288. 3. Kau ST, Howe BB, Li JH, Smith LH, Keddie JR, Barlow JJ, Giles RE, Goldberg ME. ICI 147,798: a novel diuretic agent with beta adrenoceptor blocking activity. J Pharmacol Exp Ther. 1987 Sep;242(3):818-26. PMID: 2888873.