Synonym
Diprafenone HCl; Diprafenone hydrochloride
IUPAC/Chemical Name
(+/-)-2'-(2-Hydroxy-3-(tert-pentylamino)propoxy)-3-phenylpropiophenone hydrochloride
InChi Key
UMNNDKJVNNYLDU-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H31NO3.ClH/c1-4-23(2,3)24-16-19(25)17-27-22-13-9-8-12-20(22)21(26)15-14-18-10-6-5-7-11-18;/h5-13,19,24-25H,4,14-17H2,1-3H3;1H
SMILES Code
O=C(C1=CC=CC=C1OCC(O)CNC(C)(C)CC)CCC2=CC=CC=C2.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
405.96
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Diprafenone. Drugs R D. 1999 Apr;1(4):301-3. doi: 10.2165/00126839-199901040-00004. PMID: 10566049.
2: Groschner K, Lindner W, Schnedl H, Kukovetz WR. The effects of the stereoisomers of propafenone and diprafenone in guinea-pig heart. Br J Pharmacol. 1991 Mar;102(3):669-74. doi: 10.1111/j.1476-5381.1991.tb12231.x. PMID: 1364837; PMCID: PMC1917929.
3: Koytchev R, Alken RG, Mayer O. Effect of diprafenone on the pharmacokinetics of digoxin. Eur J Clin Pharmacol. 1996;50(1-2):97-100. doi: 10.1007/s002280050075. PMID: 8739818.
4: Hinderling PH, Tendolkar A, Dee CM, Barr WH, Seiberling M, Duerr H. Single- dose interaction study of diprafenone HCl and propranolol HCl in healthy volunteers. J Clin Pharmacol. 1995 Jul;35(7):721-9. doi: 10.1002/j.1552-4604.1995.tb04113.x. PMID: 7560253.
5: Greenberg S, Cantor E, Paul J. Beta-adrenoceptor blocking activity of diprafenone in anesthetized dogs: comparison with propafenone and propranolol. J Cardiovasc Pharmacol. 1989 Sep;14(3):444-53. doi: 10.1097/00005344-198909000-00014. PMID: 2476625.
6: Nanoff C, Schütz W. Characterization of the beta-adrenoceptor blocking property of diprafenone in rats: stereoselective interaction, subtype specificity, and sensitization. J Cardiovasc Pharmacol. 1991 Dec;18(6):837-42. doi: 10.1097/00005344-199112000-00008. PMID: 1725895.
7: Trenk D, Wagner F, Sachs W, Jähnchen E. Pharmacokinetic characterization of the antiarrhythmic drug diprafenone in man. Eur J Clin Pharmacol. 1989;37(3):313-6. doi: 10.1007/BF00679792. PMID: 2612546.
8: Brunner F, Kolmayr U, Kukovetz WR. Pharmacokinetics and metabolism of the antiarrhythmic agent [3H]-diprafenone in the rat. Arzneimittelforschung. 1989 Nov;39(11):1430-5. PMID: 2619776.
9: Geibel A, Zehender M, Hohnloser S, Landsrath C, Meinertz T, Just H. Diprafenon--Vergleichsstudie zur antiarrhythmischen Therapie mit Propafenon [Diprafenone--comparative study of anti-arrhythmia therapy with propafenone]. Z Kardiol. 1988 Jul;77(7):464-9. German. PMID: 2463720.
10: Kodama I, Suzuki R, Honjo H, Toyama J. Electrophysiological effects of diprafenone, a dimethyl congener of propafenone on guinea-pig ventricular cells. Br J Pharmacol. 1992 Nov;107(3):813-20. doi: 10.1111/j.1476-5381.1992.tb14529.x. PMID: 1335340; PMCID: PMC1907742.
