MedKoo Cat#: 576474 | Name: ICI-105552

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-105552 is an aldose reductase inhibitor.

Chemical Structure

ICI-105552
ICI-105552
CAS#81420-31-7

Theoretical Analysis

MedKoo Cat#: 576474

Name: ICI-105552

CAS#: 81420-31-7

Chemical Formula: C19H14Cl2NNaO3

Exact Mass: 397.0248

Molecular Weight: 398.21

Elemental Analysis: C, 57.31; H, 3.54; Cl, 17.80; N, 3.52; Na, 5.77; O, 12.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ICI-105552; ICI105552; ICI 105552
IUPAC/Chemical Name
4-Quinolineacetic acid, 1-((3,4-dichlorophenyl)methyl)-1,2-dihydro-3-methyl-2-oxo-, sodium salt
InChi Key
AGXORWCKWUILLU-UHFFFAOYSA-M
InChi Code
InChI=1S/C19H15Cl2NO3.Na/c1-11-14(9-18(23)24)13-4-2-3-5-17(13)22(19(11)25)10-12-6-7-15(20)16(21)8-12;/h2-8H,9-10H2,1H3,(H,23,24);/q;+1/p-1
SMILES Code
[Na+].CC1=C(CC(=O)[O-])c2ccccc2N(Cc3ccc(Cl)c(Cl)c3)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 398.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Bhatnagar A, Liu SQ, Das B, Ansari NH, Srivastava SK. Inhibition kinetics of human kidney aldose and aldehyde reductases by aldose reductase inhibitors. Biochem Pharmacol. 1990 Mar 15;39(6):1115-24. doi: 10.1016/0006-2952(90)90292-s. PMID: 2157439. 2. Poulsom R, Mirrlees DJ, Earl DC, Heath H. The effects of an aldose reductase inhibitor upon the sorbitol pathway, fructose-1-phosphate and lactate in the retina and nerve of streptozotocin-diabetic rats. Exp Eye Res. 1983 May;36(5):751-60. doi: 10.1016/0014-4835(83)90112-4. PMID: 6406254. 3. Poulsom R, Heath H. Inhibition of aldose reductase in five tissues of the streptozotocin-diabetic rat. Biochem Pharmacol. 1983 May 1;32(9):1495-9. doi: 10.1016/0006-2952(83)90471-9. PMID: 6407486.