Octenidine Dihydrochloride | CAS# 70775-75-6 (2HCl) | Antimicrobial agent

MedKoo Cat#: 561588 | Name: Octenidine Dihydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Octenidine is an antimicrobial agent. It is active against a variety of bacteria, including methicillin-sensitive and -resistant S. aureus, vancomycin-resistant Enterococcus, E. faecalis, and S. pneumoniae (MICs = 1-32 mg/L), and the fungus C. albicans (MIC = 1 mg/L). Octenidine (2 mM) reduces methicillin- or vancomycin-resistant S. aureus biofilm formation. Topical application of octenidine (1%) reduces dental plaque accumulation in cynomolgus monkeys fed a high-sucrose diet.

Chemical Structure

Octenidine Dihydrochloride

CAS#70775-75-6 (2HCl)

Theoretical Analysis

MedKoo Cat#: 561588

Name: Octenidine Dihydrochloride

CAS#: 70775-75-6 (2HCl)

Chemical Formula: C36H64Cl2N4

Exact Mass:

Molecular Weight: 623.83

Elemental Analysis: C, 69.31; H, 10.34; Cl, 11.37; N, 8.98

Price and Availability

Size	Price	Availability
1g	USD 200.00	2 Weeks
5g	USD 390.00	2 Weeks
10g	USD 780.00	2 Weeks
25g	USD 1,120.00	2 Weeks

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Related CAS #

86767-75-1 (saccharin); 71251-02-0 (free base); 70775-75-6 (2HCl)

Synonym

Octenidine Dihydrochloride; Octenidine 2HCl; OCT; WIN 41,464-2; WIN41,464-2; WIN-41,464-2; WIN 41,4642; WIN 41,464-2; WIN 41,464 2;

IUPAC/Chemical Name

N-Octyl-1-[10-(4-octyliminopyridin-1-yl)decyl]pyridin-4-imine Dihydrochloride

InChi Key

SMGTYJPMKXNQFY-UHFFFAOYSA-N

InChi Code

InChI=1S/C36H62N4.2ClH/c1-3-5-7-9-15-19-27-37-35-23-31-39(32-24-35)29-21-17-13-11-12-14-18-22-30-40-33-25-36(26-34-40)38-28-20-16-10-8-6-4-2;;/h23-26,31-34H,3-22,27-30H2,1-2H3;2*1H

SMILES Code

CCCCCCCC/N=C1C=CN(CCCCCCCCCCN(C=C/2)C=CC2=N/CCCCCCCC)C=C/1.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	DMF	10.0	16.03
	DMSO	5.0	8.02
	Ethanol	30.0	48.09
	Ethanol:PBS (pH 7.2) (1:7)	0.1	0.19

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 623.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Aung AH, Kyaw WM, Heng YK, Tey HL, Ang B, Chow A. Intranasal octenidine for methicillin-resistant Staphylococcus aureus (MRSA) carriers and universal octenidine bathing reduced MRSA acquisition in an acute-care general ward. Infect Control Hosp Epidemiol. 2021 Jul 16:1-4. doi: 10.1017/ice.2021.300. Epub ahead of print. PMID: 34266515. 2: Grover V, Mahendra J, Gopalakrishnan D, Jain A. Effect of octenidine mouthwash on plaque, gingivitis, and oral microbial growth: A systematic review. Clin Exp Dent Res. 2021 Jul 6. doi: 10.1002/cre2.386. Epub ahead of print. PMID: 34227746. 3: Rzycki M, Drabik D, Szostak-Paluch K, Hanus-Lorenz B, Kraszewski S. Unraveling the mechanism of octenidine and chlorhexidine on membranes: does electrostatics matter? Biophys J. 2021 Jun 29:S0006-3495(21)00514-2. doi: 10.1016/j.bpj.2021.06.027. Epub ahead of print. PMID: 34214528. 4: Pradhan PK, Sahoo KC, Ghosh K, Lata S, Patri G, Bhol S. Does Cavity Disinfectant Affect Sealing Ability of Universal Self-etch Adhesive? J Contemp Dent Pract. 2021 Mar 1;22(3):273-277. PMID: 34210928. 5: Nizioł M, Paleczny J, Junka A, Shavandi A, Dawiec-Liśniewska A, Podstawczyk D. 3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications. Bioengineering (Basel). 2021 Jun 8;8(6):79. doi: 10.3390/bioengineering8060079. PMID: 34201362; PMCID: PMC8227034. 6: Salisbury AM, Mullin M, Chen R, Percival SL. Antibiofilm Efficacy of Polihexanide, Octenidine and Sodium Hypochlorite/Hypochlorous Acid Based Wound Irrigation Solutions against Staphylococcus aureus, Pseudomonas aeruginosa and a Multispecies Biofilm. Adv Exp Med Biol. 2021 Jun 26. doi: 10.1007/5584_2021_645. Epub ahead of print. PMID: 34173213. 7: Gold NA, Mirza TM, Avva U. Alcohol Sanitizer. 2021 Jun 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30020626. 8: Silva-Neves V, Hugo V, Alves P, Amado JC, Pais-Vieira C, Sousa F, Cerqueira F, Pinto E, Pais-Vieira M. Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions. Sci Rep. 2021 Jun 17;11(1):12789. doi: 10.1038/s41598-021-92111-4. PMID: 34140577; PMCID: PMC8211768. 9: Bardoňová L, Kotzianová A, Skuhrovcová K, Židek O, Bártová T, Kulhánek J, Hanová T, Mamulová Kutláková K, Vágnerová H, Krpatová V, Knor M, Starigazdová J, Holomková P, Buffa R, Velebný V. Antimicrobial nanofibrous mats with controllable drug release produced from hydrophobized hyaluronan. Carbohydr Polym. 2021 Sep 1;267:118225. doi: 10.1016/j.carbpol.2021.118225. Epub 2021 May 19. PMID: 34119178. 10: Xiang L, Rojo R, Prados-Frutos JC. Evaluation of the Efficacy of Lacer HaliTM Treatment on the Management of Halitosis: A Randomized Double- Blind Clinical Trial. J Clin Med. 2021 May 23;10(11):2256. doi: 10.3390/jcm10112256. PMID: 34071005; PMCID: PMC8197132. 11: Stuermer EK, Plattfaut I, Dietrich M, Brill F, Kampe A, Wiencke V, Ulatowski A, Geffken M, Rembe JD, Naumova EA, Debus SE, Smeets R. In vitro Activity of Antimicrobial Wound Dressings on P. aeruginosa Wound Biofilm. Front Microbiol. 2021 May 14;12:664030. doi: 10.3389/fmicb.2021.664030. PMID: 34054768; PMCID: PMC8160304. 12: Krupka M, Bożek A, Bartusik-Aebisher D, Cieślar G, Kawczyk-Krupka A. Photodynamic Therapy for the Treatment of Infected Leg Ulcers-A Pilot Study. Antibiotics (Basel). 2021 Apr 29;10(5):506. doi: 10.3390/antibiotics10050506. PMID: 33946775; PMCID: PMC8145697. 13: Dydak K, Junka A, Dydak A, Brożyna M, Paleczny J, Fijalkowski K, Kubielas G, Aniołek O, Bartoszewicz M. In Vitro Efficacy of Bacterial Cellulose Dressings Chemisorbed with Antiseptics against Biofilm Formed by Pathogens Isolated from Chronic Wounds. Int J Mol Sci. 2021 Apr 13;22(8):3996. doi: 10.3390/ijms22083996. PMID: 33924416; PMCID: PMC8069587. 14: Varghese VS, Kurian N. Effect of duration and dilution on antimicrobial efficacy of octenidine hydrochloride as an intracanal medicament with chitosan carrier against Enterococcus faecalis - A modified direct contact test. J Conserv Dent. 2020 Sep-Oct;23(5):463-467. doi: 10.4103/JCD.JCD_472_20. Epub 2021 Feb 10. PMID: 33911354; PMCID: PMC8066679. 15: Pavlík V, Sobotka L, Pejchal J, Čepa M, Nešporová K, Arenbergerová M, Mrózková A, Velebný V. Silver distribution in chronic wounds and the healing dynamics of chronic wounds treated with dressings containing silver and octenidine. FASEB J. 2021 May;35(5):e21580. doi: 10.1096/fj.202100065R. PMID: 33908652. 16: Sabanceva EG, Dmitrieva NA, Avramenko EA, Ivanova EV, Ezhova EG, Pochivalin VP. Otsenka effektivnosti primeneniya opolaskivatelya, soderzhashchego antiseptik oktenidina digidrokhlorid [Evaluation of effectiveness of a mouthwash containing antiseptic octenidine dihydrochloride]. Stomatologiia (Mosk). 2021;100(2):32-39. Russian. doi: 10.17116/stomat202110002132. PMID: 33874658. 17: Günther F, Blessing B, Dapunt U, Mischnik A, Mutters NT. Ability of chlorhexidine, octenidine, polyhexanide and chloroxylenol to inhibit metabolism of biofilm-forming clinical multidrug-resistant organisms. J Infect Prev. 2021 Jan;22(1):12-18. doi: 10.1177/1757177420963829. Epub 2020 Oct 20. PMID: 33841557; PMCID: PMC7841706. 18: Stuermer EK, Besser M, Brill F, Geffken M, Plattfaut I, Severing AL, Wiencke V, Rembe JD, Naumova EA, Kampe A, Debus S, Smeets R. Comparative analysis of biofilm models to determine the efficacy of antimicrobials. Int J Hyg Environ Health. 2021 May;234:113744. doi: 10.1016/j.ijheh.2021.113744. Epub 2021 Mar 26. PMID: 33780904. 19: McLain NE, Moore ZE, Avsar P. Wound cleansing for treating venous leg ulcers. Cochrane Database Syst Rev. 2021 Mar 10;3(3):CD011675. doi: 10.1002/14651858.CD011675.pub2. PMID: 33734426; PMCID: PMC8092712. 20: Reda B, Dudek J, Martínez-Hernández M, Hannig M. Effects of Octenidine on the Formation and Disruption of Dental Biofilms: An Exploratory In Situ Study in Healthy Subjects. J Dent Res. 2021 Aug;100(9):950-959. doi: 10.1177/0022034521999044. Epub 2021 Mar 18. PMID: 33733895.