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MedKoo Cat#: 413764 | Name: Dimethoxanate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimethoxanate is an antitussive

Chemical Structure

Dimethoxanate
CAS#477-93-0 (free base)

Theoretical Analysis

MedKoo Cat#: 413764

Name: Dimethoxanate

CAS#: 477-93-0 (free base)

Chemical Formula: C19H22N2O3S

Exact Mass: 358.1351

Molecular Weight: 358.46

Elemental Analysis: C, 63.66; H, 6.19; N, 7.82; O, 13.39; S, 8.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
518-63-8 (HCl) 477-93-0 (free base)
Synonym
Dimethoxanate
IUPAC/Chemical Name
10H-Phenothiazine-10-carboxylic acid, 2-(2-(dimethylamino)ethoxy)ethyl ester
InChi Key
OOVJCSPCMCAXEX-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H22N2O3S/c1-20(2)11-12-23-13-14-24-19(22)21-15-7-3-5-9-17(15)25-18-10-6-4-8-16(18)21/h3-10H,11-14H2,1-2H3
SMILES Code
O=C(N1C2=C(C=CC=C2)SC3=CC=CC=C13)OCCOCCN(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 358.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: KLEIN B. The cough sirup as palliative therapy; a clinical evaluation of dimethoxanate. Antibiotic Med Clin Ther (New York). 1958 Jul;5(7):462-5. PMID: 13559964. 2: Guo Y, Dai J, Qian G, Guo N, Ma Z, Guo X. Determination of nifedipine in human plasma and its use in bioequivalence study. Int J Pharm. 2007 Aug 16;341(1-2):91-6. doi: 10.1016/j.ijpharm.2007.03.053. Epub 2007 Apr 8. PMID: 17507190. 3: PARISH FA. Clinical evaluation of the antitussive, dimethoxanate. Med Times. 1959 Nov;87:1488-90. PMID: 14430450. 4: Klein M, Musacchio JM. High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents. J Pharmacol Exp Ther. 1989 Oct;251(1):207-15. PMID: 2477524. 5: Craviso GL, Musacchio JM. High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments. Mol Pharmacol. 1983 May;23(3):629-40. PMID: 6865909. 6: Guerrin F, Paris JC, Paris J. Action du diméthoxanate sur la contractilité de la vésicule biliaire isolée de cobaye [Effect of dimethoxanate on the contractility of the isolated guinea pig gallbladder]. C R Seances Soc Biol Fil. 1967;161(6):1322-3. French. PMID: 4232803.