MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 464424 | Name: Podophyllum resin
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Podophyllin is an alcoholic plant extract, obtained from the dried rhizome and roots of Podoplryllui emodi. It is a powder with colors varying from light brown to greenish-yellow and exposure to heat or light turns it darker. Podophyllin is used to treat condylomata acuminate, a type of venereal warts. It exhibit several biological functions and is mainly used in the treatment of constipation, hepatic disorder and rheumatic arthritis.

Chemical Structure

Podophyllum resin
Podophyllum resin
CAS#9000-55-9

Theoretical Analysis

MedKoo Cat#: 464424

Name: Podophyllum resin

CAS#: 9000-55-9

Chemical Formula: mixture

Exact Mass: 0.0000

Molecular Weight: 0.00

Elemental Analysis: mixture

Price and Availability

Size Price Availability Quantity
25g USD 450.00 2 Weeks
100g USD 750.00 2 Weeks
500g USD 2,950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Podophyllum resin; podophyllum; podophyllin; Podofillina;
IUPAC/Chemical Name
(5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
InChi Key
YJGVMLPVUAXIQN-XVVDYKMHSA-N
InChi Code
InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
SMILES Code
COc1c(OC)c(OC)cc([C@H]2[C@@H]3[C@@H]([C@H](c4c2cc5c(OCO5)c4)O)COC3=O)c1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Podophyllum resin is a resin made from the roots of the American mandrake.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Amo-Navarrete J, García-Oreja S, León-Herce D, Navarro-Pérez D, Lázaro- Martínez JL, Álvaro-Afonso FJ. Cantharidin (1%), podophyllin (5%), and salicylic acid (30%) formulation in recalcitrant plantar warts: Analysis of 48 patients. J Med Virol. 2024 Sep;96(9):e29925. doi: 10.1002/jmv.29925. PMID: 39295250. 2: Yusuf H, Purwoko MIH. Successful combination therapy of trichloroacetic acid, podophyllin, and electrocautery on giant condylomata acuminata. Int J STD AIDS. 2024 Aug 28:9564624241276574. doi: 10.1177/09564624241276574. Epub ahead of print. PMID: 39194148. 3: Rusia K, Madke B, Kashikar Y. Case Report: Concomitant presence of two STIs in a male patient. F1000Res. 2024 Jun 12;12:706. doi: 10.12688/f1000research.134667.2. PMID: 39156921; PMCID: PMC11329861. 4: Thekkayil SSM, Golani M, Mahalakshmi M, Golani D, Kalra TS, Yadav R. Podophyllin Toxicity: Case Report of a Rare Poisoning. J Assoc Physicians India. 2024 Jul;72(7):97-99. doi: 10.59556/japi.72.0406. PMID: 38990594. 5: Nobre DAB, Moura MDG, de Arruda JAA, Felix FA, Diniz PB, Duarte ECB, Abreu LG, Gomez RS, Mesquita RA. Identification of Epstein-Barr virus after topical treatment for oral hairy leukoplakia: A preliminary study. Int J STD AIDS. 2024 Jul;35(8):627-634. doi: 10.1177/09564624241246298. Epub 2024 Apr 12. PMID: 38606785. 6: Zayan H, Hosny AH, Mamdouh MM, Tawfik YM. Efficacy of Intralesional Candida Antigen Versus Measles, Mumps, and Rubella Vaccine Versus Topical Podophyllin in Treatment of Resistant Genital Warts. J Cutan Med Surg. 2024 May- Jun;28(3):253-258. doi: 10.1177/12034754241238012. Epub 2024 Mar 18. PMID: 38497287. 7: Ghayour AH, Delavari M, Arbabi M. Antileishmanial effect of podophyllotoxin and podophyllin on Leishmania major in vitro and in vivo. J Parasit Dis. 2024 Mar;48(1):157-162. doi: 10.1007/s12639-024-01654-6. Epub 2024 Feb 25. PMID: 38440762; PMCID: PMC10908768. 8: Sharquie K, Jabbar RI, Schwartz RA, Lambert MW, Lambert WC. Xeroderma Pigmentosum: Part Two: Treatment of Skin Tumors with Topical Podophyllin 25% in Benzoin. Skinmed. 2023 Nov 10;21(5):337-340. PMID: 37945359. 9: Sharquie K, Jabbar RI, Schwartz RA, Lambert MW, Lambert WC. Xeroderma Pigmentosum: Novel Prophylactic and Therapeutic Approaches. Part One: Topical Zinc Sulfate 25% and Heat Dermabrasion plus Topical Trichloroacetic Acid. Skinmed. 2023 Nov 10;21(5):330-335. PMID: 37945358. 10: Achdiat PA, Andiani S, Hindritiani R, Gondokaryono SP, Nuzuliyah G, Usman HA, Maharani RH. Molluscum Contagiosum in HIV Patient Treated with 20% Topical Glycolic Acid After Resistance with Topical Tretinoin. Clin Cosmet Investig Dermatol. 2023 Sep 29;16:2749-2755. doi: 10.2147/CCID.S423304. PMID: 37794945; PMCID: PMC10546996. 11: Euwema MS, Swanson TJ. Deadly Single Dose Agents. 2023 Jul 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 28722879. 12: Sardana K, Rose Mathachan S. Iatrogenic irritant contact dermatitis to podophyllin and the perils of look-alike, sound-alike trade names in dermatology. Indian J Dermatol Venereol Leprol. 2023 [SEASON];90(1):110-112. doi: 10.25259/IJDVL_72_2023. PMID: 37317734. 13: Khajavirad N, Daftari G, Jelodar MR. Hemolysis and acquired methemoglobinemia associated with lidocaine and benzocaine topical application: a case report. J Med Case Rep. 2023 Apr 20;17(1):146. doi: 10.1186/s13256-023-03898-x. PMID: 37076913; PMCID: PMC10116714. 14: Halim HM, Ahmed SFAE, Eyada MM. Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts. Int J STD AIDS. 2023 Aug;34(9):641-648. doi: 10.1177/09564624231169330. Epub 2023 Apr 5. PMID: 37018551. 15: Tomić L, Skerlev M, Ljubojević Hadžavdić S. Meatal Intraurethral Warts Successfully Treated with 5-fluorouracil Cream. Acta Dermatovenerol Croat. 2022 Nov;30(3):188-191. PMID: 36812280. 16: Musaddique Ansari SM, Gupta A, Nayak CS. Bowen's disease on two different unrelated anatomical sites (genitals and nail) in succession in an immunocompromised patient. Indian J Sex Transm Dis AIDS. 2022 Jul- Dec;43(2):189-191. doi: 10.4103/ijstd.ijstd_2_22. Epub 2022 Nov 17. PMID: 36743119; PMCID: PMC9891023. 17: Kim EJ, Lee JC, Lyu DH, Choi U, Choi JB, Kim KS, Park BH, Kim S, Lee SJ, Han CH, Bae S. Trends of genital wart in Korea according to treatment method classification: Big data analysis of health care in 2010-2019. Investig Clin Urol. 2023 Jan;64(1):56-65. doi: 10.4111/icu.20220318. PMID: 36629066; PMCID: PMC9834563. 18: Navarro-Pérez D, García-Oreja S, Álvaro-Afonso FJ, López-Moral M, García- Madrid M, Lázaro-Martínez JL. Cantharidin-Podophyllin-Salicylic Acid Formulation as a First-Line Treatment for Plantar Warts? A Case Report with Multiple Plantar Warts of Human Papillomavirus Biotype 27 and Previous Failed Treatments. Am J Case Rep. 2022 Nov 9;23:e937867. doi: 10.12659/AJCR.937867. PMID: 36348614; PMCID: PMC9662077. 19: Jiamton S, Chanyachailert P, Nanchaipruek Y, Jantanapornchai N, Patthamalai P, Limphoka P, Nokdhes YN, Jantaravinid J. Efficacy and Safety of Clinacanthus nutans Lindau Cream vs. Podophyllin for the Treatment of Adults with Condyloma Acuminata. Evid Based Complement Alternat Med. 2022 Jun 23;2022:1577716. doi: 10.1155/2022/1577716. PMID: 35783521; PMCID: PMC9246565. 20: Boda D, Cutoiu A, Bratu D, Bejinariu N, Crutescu R. Buschke-Löwenstein tumors: A series of 7 case reports. Exp Ther Med. 2022 Jun;23(6):393. doi: 10.3892/etm.2022.11320. Epub 2022 Apr 13. PMID: 35495587; PMCID: PMC9047027.