Synonym
Isoxsuprine Free Base; Vasodilian; Vasosurpine; Dilavase; Duvadilan; Isoxuprine
IUPAC/Chemical Name
Benzenemethanol, 4-hydroxy-alpha-(1-((1-methyl-2-phenoxyethyl)amino)ethyl)-
InChi Key
BMUKKTUHUDJSNZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H23NO3/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15/h3-11,13-14,18-21H,12H2,1-2H3
SMILES Code
OC(C(NC(C)COC1=CC=CC=C1)C)C2=CC=C(O)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
301.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Erkert RS, Macallister CG. Isoxsuprine hydrochloride in the horse: a review. J Vet Pharmacol Ther. 2002 Apr;25(2):81-7. doi: 10.1046/j.1365-2885.2002.00386.x. PMID: 12000527.
2: Shiri F, Shahraki S, Shahriyar A, Majd MH. Exploring isoxsuprine hydrochloride binding with human serum albumin in the presence of folic acid and ascorbic acid using multispectroscopic and molecular modeling methods. J Photochem Photobiol B. 2017 May;170:152-163. doi: 10.1016/j.jphotobiol.2017.04.007. Epub 2017 Apr 11. PMID: 28432945.
3: Jaju PB. Effectiveness and Safety of Isoxsuprine Hydrochloride as Tocolytic Agent in Arresting Active/Threatened Preterm Labor and Its Role in Maintenance Tocolysis: A Prospective, Open-Label Study. Am J Perinatol. 2021 Feb;38(3):291-295. doi: 10.1055/s-0039-1696720. Epub 2019 Sep 24. PMID: 31550735.
4: Medina-Ruiz D, Erreguin-Luna B, Luna-Vázquez FJ, Romo-Mancillas A, Rojas- Molina A, Ibarra-Alvarado C. Vasodilation Elicited by Isoxsuprine, Identified by High-Throughput Virtual Screening of Compound Libraries, Involves Activation of the NO/cGMP and H₂S/KATP Pathways and Blockade of α₁-Adrenoceptors and Calcium Channels. Molecules. 2019 Mar 11;24(5):987. doi: 10.3390/molecules24050987. PMID: 30862086; PMCID: PMC6429095.
5: Shahraki S, Delarami HS, Saeidifar M, Nejat R. Catalytic activity and structural changes of catalase in the presence of Levothyroxine and Isoxsuprine hydrochloride. Int J Biol Macromol. 2020 Jun 1;152:126-136. doi: 10.1016/j.ijbiomac.2020.02.064. Epub 2020 Feb 8. PMID: 32045611.
6: Shahraki S, Shiri F. Binding interaction of isoxsuprine hydrochloride and levothyroxine to milk β-lactoglobulin; from the perspective of comparison. Int J Biol Macromol. 2018 Apr 1;109:576-588. doi: 10.1016/j.ijbiomac.2017.12.117. Epub 2017 Dec 21. PMID: 29275203.
7: Saad AS, Elzanfaly ES, Halim MK, Kelani KM. Comparing the predictability of different chemometric models over UV-spectral data of isoxsuprine and its toxic photothermal degradation products. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Aug 5;219:444-449. doi: 10.1016/j.saa.2019.04.064. Epub 2019 May 1. PMID: 31063959.
8: Hill JW, Thompson JF, Carter MB, Edwards BS, Sklar LA, Rosenberg GA. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7;9(5):e96761. doi: 10.1371/journal.pone.0096761. PMID: 24804769; PMCID: PMC4013073.
9: Groot MJ, Lasaroms JJ, Van Hende J, Nielen MW. Veterinary treatment of cows with isoxsuprine for a caesarian section may temporarily lead to residues in hair of both cow and calf. Drug Test Anal. 2012 Jun;4(6):515-8. doi: 10.1002/dta.272. Epub 2011 Mar 5. PMID: 21381222.
10: Elliott J. Isoxsuprine: more questions than answers. Equine Vet J. 2000 Mar;32(2):90-1. doi: 10.2746/042516400777591507. PMID: 10743962.
