Difluoropine | CAS# 156774-35-5 | dopamine transporter

MedKoo Cat#: 413731 | Name: Difluoropine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Difluoropine is a potent and selective ligand for the dopamine transporter.

Chemical Structure

Difluoropine

CAS#156774-35-5

Theoretical Analysis

MedKoo Cat#: 413731

Name: Difluoropine

CAS#: 156774-35-5

Chemical Formula: C23H25F2NO3

Exact Mass: 401.1803

Molecular Weight: 401.45

Elemental Analysis: C, 68.81; H, 6.28; F, 9.46; N, 3.49; O, 11.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Difluoropine; O620; O-620; O 620

IUPAC/Chemical Name

2-Carbomethoxy-3-(bis(4-fluorophenyl)methoxy)tropane

InChi Key

XSYGBVSQKPLETJ-QAJIEZEQSA-N

InChi Code

InChI=1S/C23H25F2NO3/c1-26-18-11-12-19(26)21(23(27)28-2)20(13-18)29-22(14-3-7-16(24)8-4-14)15-5-9-17(25)10-6-15/h3-10,18-22H,11-13H2,1-2H3/t18-,19+,20?,21?/m1/s1

SMILES Code

[H][C@@]12C(C(OC)=O)C(OC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[C@@](CC1)(N2C)[H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 401.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Meltzer PC, Liang AY, Madras BK. The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites. J Med Chem. 1994 Jun 24;37(13):2001-10. doi: 10.1021/jm00039a014. PMID: 8027983. 2: Madras BK, Fahey MA, Goulet M, Lin Z, Bendor J, Goodrich C, Meltzer PC, Elmaleh DR, Livni E, Bonab AA, Fischman AJ. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. J Pharmacol Exp Ther. 2006 Nov;319(2):570-85. doi: 10.1124/jpet.106.105312. Epub 2006 Aug 2. PMID: 16885433. 3: Guo JF, Wang L, He D, Yang QH, Duan ZX, Zhang XW, Nie LL, Yan XX, Tang BS. Clinical features and [11C]-CFT PET analysis of PARK2, PARK6, PARK7-linked autosomal recessive early onset Parkinsonism. Neurol Sci. 2011 Feb;32(1):35-40. doi: 10.1007/s10072-010-0360-z. Epub 2010 Jul 7. PMID: 20607337.