MedKoo Cat#: 413714 | Name: Didesipramine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Didesipramine is used to treat depression. Desipramine is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed for mental balance.

Chemical Structure

Didesipramine
CAS#2095-95-6

Theoretical Analysis

MedKoo Cat#: 413714

Name: Didesipramine

CAS#: 2095-95-6

Chemical Formula: C17H20N2

Exact Mass: 252.1626

Molecular Weight: 252.36

Elemental Analysis: C, 80.91; H, 7.99; N, 11.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Didesipramine; GP36526; GP-36526; GP 36526
IUPAC/Chemical Name
5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-aminopropyl)-
InChi Key
XJWJQDZWUYUIEM-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20N2/c18-12-5-13-19-16-8-3-1-6-14(16)10-11-15-7-2-4-9-17(15)19/h1-4,6-9H,5,10-13,18H2
SMILES Code
NCCCN1C2=CC=CC=C2CCC3=CC=CC=C31
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 252.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gram LF, Bjerre M, Kragh-Sørensen P, Kvinesdal B, Molin J, Pedersen OL, Reisby N. Imipramine metabolites in blood of patients during therapy and after overdose. Clin Pharmacol Ther. 1983 Mar;33(3):335-42. doi: 10.1038/clpt.1983.42. PMID: 6825388. 2: Argenti D, D'Mello AP. The pharmacodynamics of desipramine and desmethyldesipramine in rats. J Pharmacol Exp Ther. 1994 Aug;270(2):512-9. PMID: 7915311. 3: Deupree JD, Montgomery MD, Bylund DB. Pharmacological properties of the active metabolites of the antidepressants desipramine and citalopram. Eur J Pharmacol. 2007 Dec 8;576(1-3):55-60. doi: 10.1016/j.ejphar.2007.08.017. Epub 2007 Aug 23. PMID: 17850785; PMCID: PMC2231336. 4: Hanson KL, VandenBrink BM, Babu KN, Allen KE, Nelson WL, Kunze KL. Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem. Drug Metab Dispos. 2010 Jun;38(6):963-72. doi: 10.1124/dmd.110.032391. Epub 2010 Mar 3. PMID: 20200233; PMCID: PMC2879960. 5: Beckett AH, Hutt AJ, Navas GE. Metabolism of imipramine in vitro: synthesis and characterization of N-hydroxydesmethylimipramine. Xenobiotica. 1983 Jul;13(7):391-405. doi: 10.3109/00498258309052277. PMID: 6659542. 6: Mancinelli A, D'Aranno V, Stasi MA, Lecci A, Borsini F, Meli A. Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat. Pharmacol Res. 1991 Jan;23(1):47-50. doi: 10.1016/s1043-6618(05)80105-7. PMID: 2047359. 7: Barkai AI, Suckow RF, Cooper TB. Imipramine and its metabolites: relationship to cerebral catecholamines in rats in vivo. J Pharmacol Exp Ther. 1984 Aug;230(2):330-5. PMID: 6747838. 8: Krulík R, Sikora J, Bures P, Fuksová K. Methylated and demethylated tricyclic antidepressants and their binding to cell membranes. Drug Metabol Drug Interact. 1991;9(3-4):283-91. doi: 10.1515/dmdi.1991.9.3-4.283. PMID: 1824081. 9: Bensoussan C, Delaforge M, Mansuy D. Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs. Biochem Pharmacol. 1995 Mar 1;49(5):591-602. doi: 10.1016/0006-2952(94)00477-4. PMID: 7887973. 10: Kelly JP, Leonard BE. An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. Eur Neuropsychopharmacol. 1999 Jan;9(1-2):101-5. doi: 10.1016/s0924-977x(98)00010-8. PMID: 10082234.