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MedKoo Cat#: 581633 | Name: Diethylamine dinitric oxide adduct

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diethylamine dinitric oxide adduct is a nitric oxide generator.

Chemical Structure

Diethylamine dinitric oxide adduct
CAS#92818-79-6

Theoretical Analysis

MedKoo Cat#: 581633

Name: Diethylamine dinitric oxide adduct

CAS#: 92818-79-6

Chemical Formula: C4H12N2O

Exact Mass: 104.0950

Molecular Weight: 104.15

Elemental Analysis: C, 46.13; H, 11.61; N, 26.90; O, 15.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Diethylamine dinitric oxide adduct; DEANO.
IUPAC/Chemical Name
diethylamine compound with nitrosyl hydride (1:1)
InChi Key
UOWHQKQTGZCVNP-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H11N.HNO/c1-3-5-4-2;1-2/h5H,3-4H2,1-2H3;1H
SMILES Code
N(CC)CC.N=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 104.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 20660605. 4: McElroy SP, Gurney AM, Drummond RM. Pharmacological profile of store-operated Ca(2+) entry in intrapulmonary artery smooth muscle cells. Eur J Pharmacol. 2008 Apr 14;584(1):10-20. doi: 10.1016/j.ejphar.2008.01.018. Epub 2008 Jan 26. PubMed PMID: 18308301. 5: Schäfer A, Flierl U, Vogt C, Menninger S, Tas P, Ertl G, Bauersachs J. Telmisartan improves vascular function and reduces platelet activation in rats with streptozotocin-induced diabetes mellitus. Pharmacol Res. 2007 Sep;56(3):217-23. Epub 2007 Jun 19. PubMed PMID: 17669665. 6: Hall CN, Garthwaite J. Inactivation of nitric oxide by rat cerebellar slices. J Physiol. 2006 Dec 1;577(Pt 2):549-67. Epub 2006 Sep 14. PubMed PMID: 16973697; PubMed Central PMCID: PMC1890435. 7: Chen JX, Ibe BO, Ma SX. Nitric oxide modulation of norepinephrine production in acupuncture points. Life Sci. 2006 Nov 2;79(23):2157-64. Epub 2006 Jul 13. PubMed PMID: 16890244. 8: Reszka KJ, McCormick ML, Buettner GR, Hart CM, Britigan BE. Nitric oxide decreases the stability of DMPO spin adducts. Nitric Oxide. 2006 Sep;15(2):133-41. Epub 2006 May 2. PubMed PMID: 16647868. 9: Sarr M, Lobysheva I, Diallo AS, Stoclet JC, Schini-Kerth VB, Muller B. Formation of releasable NO stores by S-nitrosoglutathione in arteries exhibiting tolerance to glyceryl-trinitrate. Eur J Pharmacol. 2005 Apr 18;513(1-2):119-23. Epub 2005 Apr 7. PubMed PMID: 15878716. 10: Schmidt PM, Rothkegel C, Wunder F, Schröder H, Stasch JP. Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase. Eur J Pharmacol. 2005 Apr 18;513(1-2):67-74. Epub 2005 Apr 8. PubMed PMID: 15878710. 11: Jaszewski AR, Fann YC, Chen YR, Sato K, Corbett J, Mason RP. EPR spectroscopy studies on the structural transition of nitrosyl hemoglobin in the arterial-venous cycle of DEANO-treated rats as it relates to the proposed nitrosyl hemoglobin/nitrosothiol hemoglobin exchange. Free Radic Biol Med. 2003 Aug 15;35(4):444-51. PubMed PMID: 12899946. 12: Schmidt P, Schramm M, Schröder H, Stasch JP. Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase. Eur J Pharmacol. 2003 May 16;468(3):167-74. PubMed PMID: 12754054. 13: Wang M, Obrenovitch TP, Urenjak J. Effects of the nitric oxide donor, DEA/NO on cortical spreading depression. Neuropharmacology. 2003 Jun;44(7):949-57. PubMed PMID: 12726826. 14: Thyagarajan B, Malli R, Schmidt K, Graier WF, Groschner K. Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling. Br J Pharmacol. 2002 Nov;137(6):821-30. PubMed PMID: 12411413; PubMed Central PMCID: PMC1573569. 15: Bellamy TC, Griffiths C, Garthwaite J. Differential sensitivity of guanylyl cyclase and mitochondrial respiration to nitric oxide measured using clamped concentrations. J Biol Chem. 2002 Aug 30;277(35):31801-7. Epub 2002 Jun 21. PubMed PMID: 12080082. 16: Lawler JM, Song W. Specificity of antioxidant enzyme inhibition in skeletal muscle to reactive nitrogen species donors. Biochem Biophys Res Commun. 2002 Jun 28;294(5):1093-100. PubMed PMID: 12074589. 17: Czapski GA, Avram D, Sakharov DV, Wirtz KW, Strosznajder JB, Pap EH. Activated neutrophils oxidize extracellular proteins of endothelial cells in culture: effect of nitric oxide donors. Biochem J. 2002 Aug 1;365(Pt 3):897-902. PubMed PMID: 11964140; PubMed Central PMCID: PMC1222711. 18: Abi-Gerges N, Szabo G, Otero AS, Fischmeister R, Méry PF. NO donors potentiate the beta-adrenergic stimulation of I(Ca,L) and the muscarinic activation of I(K,ACh) in rat cardiac myocytes. J Physiol. 2002 Apr 15;540(Pt 2):411-24. PubMed PMID: 11956332; PubMed Central PMCID: PMC2290242. 19: Thyagarajan B, Poteser M, Romanin C, Kahr H, Zhu MX, Groschner K. Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling: evidence for a role of Trp3 as a subunit of capacitative Ca2+ entry channels. J Biol Chem. 2001 Dec 21;276(51):48149-58. Epub 2001 Oct 12. PubMed PMID: 11600493. 20: Srivastava S, Dixit BL, Ramana KV, Chandra A, Chandra D, Zacarias A, Petrash JM, Bhatnagar A, Srivastava SK. Structural and kinetic modifications of aldose reductase by S-nitrosothiols. Biochem J. 2001 Aug 15;358(Pt 1):111-8. PubMed PMID: 11485558; PubMed Central PMCID: PMC1222038.