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MedKoo Cat#: 413709 | Name: Dicyclomine free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dicyclomine is an anticholinergic that blocks muscarinic receptors. Dicyclomine is used to treat intestinal hypermotility and the symptoms of irritable bowel syndrome (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.

Chemical Structure

Dicyclomine free base
Dicyclomine free base
CAS#77-19-0 (free base)

Theoretical Analysis

MedKoo Cat#: 413709

Name: Dicyclomine free base

CAS#: 77-19-0 (free base)

Chemical Formula: C19H35NO2

Exact Mass: 309.2668

Molecular Weight: 309.49

Elemental Analysis: C, 73.74; H, 11.40; N, 4.53; O, 10.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
67-92-5 (HCl) 77-19-0 (free base)
Synonym
Dicyclomine (free base); HSDB3058; HSDB-3058; HSDB 3058
IUPAC/Chemical Name
(1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester
InChi Key
CURUTKGFNZGFSE-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
SMILES Code
O=C(C1(C2CCCCC2)CCCCC1)OCCN(CC)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Dicyclomine. 2017 Jul 7. PMID: 31644199. 2: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Dicyclomine. 2018 Oct 31. PMID: 30000514. 3: Singh VV, Gupta S, Sarkar S, Chatterjee B. Problematic dicyclomine use: A case report and narrative review. Asian J Psychiatr. 2020 Feb;48:101891. doi: 10.1016/j.ajp.2019.101891. Epub 2019 Dec 6. PMID: 31864128. 4: Sanawar M, Saleem U, Anwar F, Nazir S, Akhtar MF, Ahmad B, Ismail T. Investigation of anti-Parkinson activity of dicyclomine. Int J Neurosci. 2020 Sep 11:1-14. doi: 10.1080/00207454.2020.1815732. Epub ahead of print. PMID: 32847457. 5: Kaako A. Probable association of acute pancreatitis with dicyclomine. Turk J Gastroenterol. 2019 Mar;30(3):307-308. doi: 10.5152/tjg.2018.18411. PMID: 30459133; PMCID: PMC6428510. 6: Sarasu JM, Narang M, Shah D. Infantile Colic: An Update. Indian Pediatr. 2018 Nov 15;55(11):979-987. Epub 2018 Jun 13. PMID: 29941700. 7: Dicyclomine for Gastrointestinal Conditions: A Review of the Clinical Effectiveness, Safety, and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Dec 3. PMID: 26985553. 8: Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes Å, Painter RC, Mullin PM. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat Rev Dis Primers. 2019 Sep 12;5(1):62. doi: 10.1038/s41572-019-0110-3. PMID: 31515515. 9: Doxylamine/pyridoxine for nausea and vomiting in pregnancy. Drug Ther Bull. 2019 Mar;57(3):38-41. doi: 10.1136/dtb.2018.000053. Epub 2019 Jan 31. PMID: 30705026. 10: Johnson JD, Cocker K, Chang E. Infantile Colic: Recognition and Treatment. Am Fam Physician. 2015 Oct 1;92(7):577-82. PMID: 26447441.