Dyclonine (free base) | CAS# 586-60-7 (free base) | oral anaesthetic

MedKoo Cat#: 413693 | Name: Dyclonine (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dyclonine (free base) is an oral anaesthetic that is the active ingredient of Sucrets, an over-the-counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.

Chemical Structure

Dyclonine (free base)

CAS#586-60-7 (free base)

Theoretical Analysis

MedKoo Cat#: 413693

Name: Dyclonine (free base)

CAS#: 586-60-7 (free base)

Chemical Formula: C18H27NO2

Exact Mass: 289.2042

Molecular Weight: 289.42

Elemental Analysis: C, 74.70; H, 9.40; N, 4.84; O, 11.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

536-43-6 (HCl) 586-60-7 (free base)

Synonym

Dyclonine (free base); Dyclonin; Dyclocaine; Diclonina; Dyclocainum; Dycloninum;

IUPAC/Chemical Name

1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)- (9CI)

InChi Key

BZEWSEKUUPWQDQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3

SMILES Code

O=C(C1=CC=C(OCCCC)C=C1)CCN2CCCCC2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 289.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Dyclonine. 2020 Nov 16. PMID: 33226748. 2: Kimyon RS, Schlarbaum JP, Liou YL, Warshaw EM, Hylwa SA. Allergic Dermatitis to Dyclonine (Dyclocaine). Dermatitis. 2019 Nov/Dec;30(6):372-373. doi: 10.1097/DER.0000000000000522. PMID: 31609856. 3: Nguyen HL, Yiannias JA. Contact Dermatitis to Medications and Skin Products. Clin Rev Allergy Immunol. 2019 Feb;56(1):41-59. doi: 10.1007/s12016-018-8705-0. PMID: 30145645. 4: Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget. 2018 Sep 18;9(73):33832-33843. doi: 10.18632/oncotarget.26112. PMID: 30333913; PMCID: PMC6173468. 5: Sahdeo S, Scott BD, McMackin MZ, Jasoliya M, Brown B, Wulff H, Perlman SL, Pook MA, Cortopassi GA. Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. Hum Mol Genet. 2014 Dec 20;23(25):6848-62. doi: 10.1093/hmg/ddu408. Epub 2014 Aug 11. PMID: 25113747; PMCID: PMC4245046. 6: Wang N, Jin F, Liu W, Dang S, Wang Y, Yan Y, Wu G. 1% Tetracaine hydrochloride injection pure solution aerosol inhalation combined with oral administration of dyclonine hydrochloride mucilage as upper airway anesthesia for bronchoscopy: A randomized controlled trial. Clin Respir J. 2020 Feb;14(2):132-139. doi: 10.1111/crj.13110. Epub 2019 Dec 5. PMID: 31746542. 7: Ju D, Xie Y. Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells. Mol Med Rep. 2014 Nov;10(5):2609-12. doi: 10.3892/mmr.2014.2522. Epub 2014 Aug 28. PMID: 25174315. 8: Jichao S, Cuida M, Mingxing C, Yunyun W, Dongdong Z. Oral dyclonine hydrochloride mucilage versus tetracaine spray in electronic flexible laryngoscopy: A prospective, randomized controlled trial. Am J Otolaryngol. 2016 Mar-Apr;37(2):169-71. doi: 10.1016/j.amjoto.2015.12.005. Epub 2015 Dec 9. PMID: 26954876. 9: DYCLONINE hydrochloride. J Am Med Assoc. 1956 Sep 8;162(2):116-7. PMID: 13357302. 10: Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, Armour CD, Bennett HA, Coffey E, Dai H, He YD, Kidd MJ, King AM, Meyer MR, Slade D, Lum PY, Stepaniants SB, Shoemaker DD, Gachotte D, Chakraburtty K, Simon J, Bard M, Friend SH. Functional discovery via a compendium of expression profiles. Cell. 2000 Jul 7;102(1):109-26. doi: 10.1016/s0092-8674(00)00015-5. PMID: 10929718.