Synonym
Dicarbine; Dicarbina; Dicarbinum
IUPAC/Chemical Name
1H-Pyrido(4,3-b)indole, 2,3,4,4a,5,9b-hexahydro-2,8-dimethyl-
InChi Key
CYJQCYXRNNCURD-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H18N2/c1-9-3-4-12-10(7-9)11-8-15(2)6-5-13(11)14-12/h3-4,7,11,13-14H,5-6,8H2,1-2H3
SMILES Code
CC1=CC2=C(NC3C2CN(C)CC3)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
202.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Valachová K, Mach M, Šoltés L. Oxidative Degradation of High-Molar-Mass Hyaluronan: Effects of Some Indole Derivatives to Hyaluronan Decay. Int J Mol Sci. 2020 Aug 5;21(16):5609. doi: 10.3390/ijms21165609. PMID: 32764392; PMCID: PMC7460571.
2: Augustyniak A, Bartosz G, Cipak A, Duburs G, Horáková L, Luczaj W, Majekova M, Odysseos AD, Rackova L, Skrzydlewska E, Stefek M, Strosová M, Tirzitis G, Venskutonis PR, Viskupicova J, Vraka PS, Zarković N. Natural and synthetic antioxidants: an updated overview. Free Radic Res. 2010 Oct;44(10):1216-62. doi: 10.3109/10715762.2010.508495. PMID: 20836663.
3: Račková L, Kuniaková M. Acidotropic properties of synthetic hexahydropyridoindole antioxidants. Gen Physiol Biophys. 2015 Oct;34(4):367-82. doi: 10.4149/gpb_2015016. PMID: 26221744.
4: Sreenilayam G, Fasan R. Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates. Chem Commun (Camb). 2015 Jan 28;51(8):1532-4. doi: 10.1039/c4cc08753d. Erratum in: Chem Commun (Camb). 2015 Jan 31;51(9):1744. PMID: 25504318; PMCID: PMC4282819.
5: Chorvatovicová D, Horváthová E, Slamenová D. Antimutagenic effects of stobadine: review of results. Life Sci. 1999;65(18-19):2015-7. doi: 10.1016/s0024-3205(99)00468-3. PMID: 10576458.
6: Stolc S, Vlkolinský R, Pavlásek J. Neuroprotection by the pyridoindole stobadine: a minireview. Brain Res Bull. 1997;42(5):335-40. doi: 10.1016/s0361-9230(96)00294-8. PMID: 9092873.
7: Bezek S, Soltés L, Scasnár V, Bauerová K, Kállay Z, Durisová M, Mihalová D, Bohov P, Faberová V, Kukan M, Trnovec T, Koprda V. Pharmacokinetic study of stobadine. Life Sci. 1999;65(18-19):2003-5. doi: 10.1016/s0024-3205(99)00465-8. PMID: 10576455.
8: Juranek I, Horakova L, Rackova L, Stefek M. Antioxidants in treating pathologies involving oxidative damage: an update on medicinal chemistry and biological activity of stobadine and related pyridoindoles. Curr Med Chem. 2010;17(6):552-70. doi: 10.2174/092986710790416317. PMID: 20015031.
9: Horáková L, Stolc S. Antioxidant and pharmacodynamic effects of pyridoindole stobadine. Gen Pharmacol. 1998 May;30(5):627-38. doi: 10.1016/s0306-3623(97)00300-5. PMID: 9559311.
10: Kuwata S, Ikariya T. Metal-ligand bifunctional reactivity and catalysis of protic N-heterocyclic carbene and pyrazole complexes featuring β-NH units. Chem Commun (Camb). 2014 Nov 28;50(92):14290-300. doi: 10.1039/c4cc04457f. PMID: 25074357.