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MedKoo Cat#: 576395 | Name: HT-74

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HT-74 is a calmodulin antagonist.

Chemical Structure

HT-74
HT-74
CAS#97467-29-3

Theoretical Analysis

MedKoo Cat#: 576395

Name: HT-74

CAS#: 97467-29-3

Chemical Formula: C29H33N3O4S2

Exact Mass: 551.1912

Molecular Weight: 551.72

Elemental Analysis: C, 63.13; H, 6.03; N, 7.62; O, 11.60; S, 11.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
HT 74; HT74; HT-74
IUPAC/Chemical Name
Benzenesulfonamide, 3-(2-benzothiazolyl)-4,5-dimethoxy-N-(3-(4-phenyl-1-piperidinyl)propyl)-
InChi Key
SKGVOFZFTDFTDP-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H33N3O4S2/c1-35-26-20-23(19-24(28(26)36-2)29-31-25-11-6-7-12-27(25)37-29)38(33,34)30-15-8-16-32-17-13-22(14-18-32)21-9-4-3-5-10-21/h3-7,9-12,19-20,22,30H,8,13-18H2,1-2H3
SMILES Code
COc1cc(cc(c1OC)c2nc3ccccc3s2)S(=O)(=O)NCCCN4CCC(CC4)c5ccccc5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 551.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Tanaka T, Umekawa H, Saitoh M, Ishikawa T, Shin T, Ito M, Itoh H, Kawamatsu Y, Sugihara H, Hidaka H. Modulation of calmodulin function and of Ca2+-induced smooth muscle contraction by the calmodulin antagonist, HT-74. Mol Pharmacol. 1986 Mar;29(3):264-9. PMID: 3005834.

View History

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