Synonym
Cefodizime disodium; Cefodizime sodium; HR221; HR-221; HR 221; THR 221; THR221; THR-221
IUPAC/Chemical Name
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio)methyl)-8-oxo-, disodium salt, (6R,7R)-
InChi Key
WBOBLQIRACJNPA-AEKYOGSZSA-L
InChi Code
InChI=1S/C20H20N6O7S4.2Na/c1-7-10(3-11(27)28)37-20(22-7)36-5-8-4-34-17-13(16(30)26(17)14(8)18(31)32)24-15(29)12(25-33-2)9-6-35-19(21)23-9;;/h6,13,17H,3-5H2,1-2H3,(H2,21,23)(H,24,29)(H,27,28)(H,31,32);;/q;2*+1/p-2/b25-12-;;/t13-,17-;;/m1../s1
SMILES Code
[Na+].[Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)[O-])CSc3nc(C)c(CC(=O)[O-])s3)\c4csc(N)n4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
628.62
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wang B, Bian R, Wei C, Sun S, Gao P. [Cefodizime increases peripheral blood CD4/CD8 and Th1/Th2 ratios in senile patients with bacterial pneumonia]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Apr;31(4):528-31. Chinese. PubMed PMID: 25854575.
2: Hu T, Liu Y. Probing the interaction of cefodizime with human serum albumin using multi-spectroscopic and molecular docking techniques. J Pharm Biomed Anal. 2015 Mar 25;107:325-32. doi: 10.1016/j.jpba.2015.01.010. Epub 2015 Jan 13. PubMed PMID: 25637820.
3: Wang P, Kan QC, Yu ZJ, Li L, Pan X. Effects of cefodizime on chemokines of liver tissues in mice with immunological hepatic injury. Chin Med J (Engl). 2011 Mar;124(5):746-50. PubMed PMID: 21518570.
4: Merighi M, Carlotto A, Guella L, Bonora S, Fibbia GC, Mazzi R, Lazzarini L, Mirandola F, Cruciani M, Concia E. Stability of cefodizime in solution and compatibility with other injectable drugs. J Chemother. 1994 Aug;6(4):243-5. PubMed PMID: 7830101.
5: Barradell LB, Brogden RN. Cefodizime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1992 Nov;44(5):800-34. Review. Erratum in: Drugs 1993 Jan;45(1):130. PubMed PMID: 1280568.
